Case 2: PART 1: LIVER, NEEDLE BIOPSY- ACTIVE HEPATITIS WITH DUCT DAMAGE(see microscopic description). PART 2: SKIN, PUNCH BIOPSY- MILD SUPERFICIAL PERIVASCULAR INFLAMMATION.
Case 3: PART 1: LIVER, SUBCAPSULAR WEDGE BIOPSY - MILDLY ACTIVE, PREDOMINANTLY MACRONODULAR CIRRHOSIS (see microscopic description and comment). PART 2: APPENDIX, RESECTION - FIBROSIS AND FOCAL CHRONIC INFLAMMATION (See microscopic description).
Case 4: LIVER, NEEDLE BIOPSY - DIFFUSE HEPATOCYTE SWELLING AND CYTOPLASMIC RAREFACTION WITH ACCUMULATED PROTEIN GLOBULES AND SUSPECTED MICROVESICULAR STEATOSIS. FOCAL NEUTROPHIL CLUSTERS IN LOBULES. PROMINENT GLYCOGENATED NUCLEI.
Case 5: LIVER, NEEDLE BIOPSY - SCATTERED EPITHELIOID GRANULOMAS WITH PERIPHERAL FIBROSIS AND MILD INFLAMMATORY ACTIVITY. FOCAL SINUSOIDAL DILATATION.
Case 6: ALLOGRAFT LIVER, NEEDLE BIOPSY - MODERATE MIXED MACRO- AND MICROVESICULAR STEATOSIS WITH MILD STEATOHEPATITIS. SCATTERED EPITHELIOID GRANULOMAS (STAINS FOR FUNGI AND AFB NEGATIVE).
Case 7: LIVER, NEEDLE BIOPSY - PORTAL AND LOBULAR HEPATITIS C WITH MILD ACTIVITY (HAI INDEX 9/22). SUBOPTIMAL SPECIMEN, INSUFFICIENT TO EVALUATE EXTENT OF FIBROSIS.
Case 8: ALLOGRAFT LIVER, NEEDLE BIOPSY - FOCAL MILD PORTAL INFLAMMATION AND BILE DUCT INJURY.
Case 9: ALLOGRAFT LIVER, NEEDLE BIOPSY - CHRONIC HEPATITIS, VIRAL TYPE B, MILD TO MODERATELY ACTIVE (HAI 8-10/22). MILD TO MODERATE PORTAL FIBROSIS WITH FOCAL BRIDGING. INDETERMINATE FOR ACUTE REJECTION(See microscopic description). MILDLY INCREASED PORTAL INFLAMMATION IN COMPARISON TO PREVIOUS BIOPSY.
Case 10: ALLOGRAFT LIVER, NEEDLE BIOPSY Part 1- ACTIVE HEPATITIS, VIRAL TYPE C, FEATURES OF ACUTE WITH TRANSITION TO CHRONICITY. FOCALLY BRIDGING FIBROSIS. SUPERIMPOSED ACUTE CELLULAR REJECTION, MILD, WITH DUCT DAMAGE(see microscopic description).
Case 11: ALLOGRAFT LIVER, NEEDLE BIOPSY - CHOLESTASIS WITH SEVERE BILE DUCT ATROPHY AND BILE DUCT LOSS INVOLVING FIVE OF THIRTEEN (5/13) PORTAL TRIADS, CHRONIC REJECTION IS FAVORED, BUT BILIARY TRACT STRICTURING SHOULD BE EXCLUDED(see microscopic description).
Case 12: LIVER, NEEDLE BIOPSY - MINIMAL PERIPORTAL REACTIVITY WITH DUCTULAR PROLIFERATION AND SCATTERED INFLAMMATORY CELLS. NO EVIDENCE OF DUCT LOSS OR INJURY.
Case 13: NATIVE LIVER, NEEDLE BIOPSY - DIFFUSE SINUSOIDAL INFILTRATE SUSPICIOUS FOR MALIGNANCY (See comment).
Case 14: ALLOGRAFT LIVER, NEEDLE BIOPSY (9 MONTHS STATUS POST ORTHOTOPIC LIVER TRANSPLANTATION) - MILD ACUTE CELLULAR REJECTION WITH PROMINENT CENTRAL VENULITIS (see microscopic description).
Case 15: LIVER MASS, RESECTION - MODERATELY WELL DIFFERENTIATED HEPATOCELLULAR CARCINOMA ARISING IN A NON-CIRRHOTIC LIVER WITH FEATURES OF FOCAL FIBROLAMELLAR DIFFERENTIATION (see microscopic description). FOCAL EQUIVOCAL MICROVASCULAR INVASION. NON-CIRRHOTIC LIVER WITH MASS EFFECT AND NON-CASEATING GRANULOMAS (see microscopic description).
Case 16: FAILED LIVER ALLOGRAFT(LIVING-RELATED DONOR), HEPATIC RE-TRANSPLANTATION: WIDESPREAD HEMORRHAGIC NECROSIS WITH FOCAL PERIPORTAL PREDOMINANCE(See microscopic description). NO DEFINITE EVIDENCE OF HUMORAL, OR ANTIBODY-MEDIATED REJECTION. FOCAL ARTERIAL THROMBOSIS. FOCAL ARTERIAL INTIMAL THICKENING, MILD PERIVENULAR AND PERICELLULAR FIBROSIS AND MILD INTRALOBULAR REGENERATIVE CHANGE(See microscopic description).
Case 17: NATIVE LIVER, NEEDLE BIOPSY - MODERATELY DIFFERENTIATED CARCINOMA COMPATIBLE WITH HEPATOCELLULAR CARCINOMA (See note). PORTAL AND LOBULAR INFLAMMATION CONSISTENT WITH CHRONIC HEPATITIS (HAI=12/22).
Case 18: ALLOGRAFT LIVER, NEEDLE BIOPSY - CHRONIC HEPATITIS WITH MILD INFLAMMATORY ACTIVITY AND PORTAL-PORTAL BRIDGING FIBROSIS. MILD CHRONIC BILE DUCT DAMAGE. NO EVIDENCE OF ACUTE REJECTION.
Case 19: PART 1: ALLOGRAFT LIVER, NEEDLE BIOPSY - ACTIVE LOBULAR HEPATITIS (See Microscopic Description). MINIMAL EVIDENCE OF ACUTE REJECTION. PART 2: ALLOGRAFT LIVER, NEEDLE BIOPSY - ACTIVE LOBULAR HEPATITIS WITH MINIMAL MIXED STEATOSIS. PERIPORTAL AND MID ZONAL HEPATOCYTE SWELLING, CONSISTENT WITH STEROID THERAPY. NO EVIDENCE OF ACUTE REJECTION.
Case 20: LIVER, NEEDLE BIOPSY - ESTABLISHED CIRRHOSIS WITH MILD TO MODERATE INFLAMMATORY ACTIVITY. MODERATE MACROVESICULAR STEATOSIS.
Case 21: PART 1: SOFT TISSUE, "LIVER BIOPSY" - MATURE ADIPOSE TISSUE WITH RECENT HEMORRHAGE AND ORGANIZATION. PART 2: LIVER, HEPATIC SEGMENT 4, RESECTION - WELL DIFFERENTIATED HEPATOCELLULAR CARCINOMA WITH FOCI OF HEMORRHAGE, NECROSIS, AND GRANULATION TISSUE (see microscopic description). NO VASCULAR INVASION IDENTIFIED; RESECTION MARGINS FREE OF TUMOR. PATHOLOGIC STAGE: T2NXMX. PART 3: LIVER, WEDGE BIOPSY - MILD PORTAL INFLAMMATION AND PORTAL FIBROSIS.
Case 22: LIVER ALLOGRAFT, NEEDLE BIOPSY - MILD ACUTE CELLULAR REJECTION WITH PROMINENT CENTRAL VENULITIS AND FOCAL HEPATOCELLULAR DROPOUT. LOBULAR DISARRAY, KUPFFER CELL HYPERTROPHY AND HEPATOCYTE REACTIVE CHANGES; HEPATITIS B VIRUS INFECTION AND SEPSIS SHOULD BE EXCLUDED (SEE MICROSCOPIC DESCRIPTION). PORTAL AND PERIPORTAL HEMORRHAGE, CAUSE UNCERTAIN.
Case 23: ALLOGRAFT LIVER, NEEDLE BIOPSY - TREATED ACUTE (CELLULAR) REJECTION, CURRENTLY, NO SIGNIFICANT ACTIVITY. LESS INFLAMMATION AND NECROSIS IN COMPARISON TO MOST RECENT PREVIOUS BIOPSY (Case 22). BILE DUCT LOSS IN TWO OF FOUR (2/4) SMALL PORTAL TRIADS AND BILIARY EPITHELIAL ATROPHY, SUGGESTIVE, BUT NOT DIAGNOSTIC OF THE EARLIEST PHASES OF CHRONIC REJECTION (see microscopic description).
Case 24: LIVER ALLOGRAFT, NEEDLE BIOPSY (APPROXIMATELY NINE MONTHS POST TRANSPLANT) - MINIMAL TO NO EVIDENCE OF ACUTE CELLULAR REJECTION. MODERATELY ACTIVE HEPATITIS, ACUTE WITH FEATURES OF TRANSITION TO CHRONICITY (SEE MICROSCOPIC DESCRIPTION) CONSISTENT WITH THE CLINICAL HISTORY OF VIRAL TYPE C (HAI=11-13/22).
Case 25: LIVER, NEEDLE BIOPSY - CHRONIC HEPATITIS, MODERATELY ACTIVE, CONSISTENT WITH VIRAL TYPE C. BRIDGING FIBROSIS/EARLY CIRRHOSIS (see microscopic description). MARKED IRON OVERLOAD PRESENT IN PERIPORTAL HEPATOCYTES, BILIARY EPITHELIUM AND RETICULOENDOTHELIAL CELLS(see microscopic description).
Case 26: LIVER, WEDGE BIOPSY - LOW GRADE HEPATOCELLULAR CARCINOMA. NO BACKGROUND LIVER PRESENT FOR EVALUATION.
Case 27: LIVER, NEEDLE BIOPSY - CHRONIC HEPATITIS, MILDLY ACTIVE, WITH CIRRHOSIS (HAI INDEX 12/22). FOCAL MACROVESICULAR STEATOSIS AND SINUSOIDAL FIBROSIS (See comment).
Case 28: PART 1: ALLOGRAFT LIVER, NEEDLE BIOPSY - MILD LOBULAR HEPATITIS WITH VIRAL INCLUSIONS CONSISTENT WITH CYTOMEGALOVIRUS. NO EVIDENCE OF ACUTE REJECTION. PART 2: ALLOGRAFT LIVER, NEEDLE BIOPSY - PORTAL DUCTULAR RESPONSE WITH REACTIVE LOBULAR CHANGES. >NO VIRAL INCLUSIONS IDENTIFIED, BUT IMMUNOSTAINS POSITIVE FOR A SINGLE CMV INCLUSION. NO EVIDENCE OF ACUTE REJECTION. PART 3: ALLOGRAFT LIVER, NEEDLE BIOPSY - PORTAL EXPANSION WITH DUCTULAR REACTION (EXCLUDE DUCT STRICTURE OR OTHER FORM OF BILIARY OBSTRUCTION). NO EVIDENCE OF ACUTE REJECTION.
Case 29: PART 1: GALLBLADDER, CHOLECYSTECTOMY - CHANGES CONSISTENT WITH RESOLVING ACUTE CHOLECYSTITIS. PART 2: LIVER, NEEDLE BIOPSY - BILIARY FIBROSIS WITH DEVELOPING CIRRHOSIS AND MILD INFLAMMATORY ACTIVITY. NO BILE DUCT LOSS, FLORID DUCT LESIONS, OR GRANULOMAS IDENTIFIED.
Case 30: LIVER, NEEDLE BIOPSY - LOW GRADE SPINDLE CELL SARCOMA (See comment).
Case 31: ALLOGRAFT LIVER, NEEDLE BIOPSY - MINIMAL TO NO EVIDENCE OF ACUTE REJECTION. CHRONIC HEPATITIS, CONSISTENT WITH THE CLINICAL HISTORY OF RECURRENT VIRAL TYPE C, MILDLY ACTIVE (HAI 6-10/22). MILD TO MODERATE PORTAL FIBROSIS (see microscopic description).
Case 32: FAILED LIVER ALLOGRAFT, HEPATIC RETRANSPLANTATION PROCEDURE - FOAM CELL OBLITERATIVE ARTERIOPATHY WITH ACTIVE LYMPHOCYTIC ARTERITIS, BILE DUCT LOSS, CONGESTION, HEMORRHAGE AND MARKED CHOLESTASIS, ALL INDICATIVE OF CHRONIC REJECTION, WHICH LIKELY EVOLVED FROM ACUTE REJECTION (see microscopic description). (stains for hepatitis B core and surface antigens are suggested.)
Case 33: ALLOGRAFT LIVER, NEEDLE BIOPSY - LOBULAR REACTIVITY AND SPOTTY NECROSIS, COMPATIBLE WITH PRIOR HISTORY OF CMV HEPATITIS. NO VIRAL INCLUSIONS SEEN ON ROUTINE HISTOLOGIC PREPARATION OR BY IMMUNOHISTOCHEMISTRY STAINING. MINIMAL COMPONENT OF ACUTE CELLULAR REJECTION (RAI 2-3/9).
Case 34: LIVER ALLOGRAFT, NEEDLE BIOPSY - NO EVIDENCE OF ACUTE REJECTION (RAI 0/9). CHANGES CONSISTENT WITH SEVERE PRESERVATION INJURY AND/OR SEPSIS. MARKED PORTAL EXPANSION WITH PORTAL TO PORTAL BRIDGING FIBROSIS. FOCAL INTRAHEPATIC PORTAL VEIN THROMBOSIS.
Case 35: LIVER, NEEDLE BIOPSY - ADVANCED MICRONODULAR CIRRHOSIS WITH MINIMAL INFLAMMATORY ACTIVITY. NO SPECIFIC ETIOLOGIC CLUES IDENTIFIED (see microscopic description).
Case 36: LIVER, NEEDLE BIOPSY - WELL DIFFERENTIATED HEPATOCELLULAR CARCINOMA. FOCAL FIBROSIS, SUGGESTIVE OF UNDERLYING CHRONIC LIVER DISEASE (see microscopic description).
Case 37: LIVER, NEEDLE BIOPSY - ATYPICAL VASCULAR PROLIFERATION CONSISTENT WITH LOW GRADE VASCULAR MALIGNANCY (See Microscopic).
Case 38: LIVER, NEEDLE BIOPSY - HISTOLOGIC FEATURES CHARACTERISTIC OF PRIMARY BILIARY CIRRHOSIS. BRIDGING FIBROSIS WITH FOCAL ARCHITECTURAL DISTORTION (STAGE III).
Case 39: LIVER, LAPAROSCOPIC BIOPSY - BENIGN HEPATOCELLULAR NEOPLASM CONSISTENT WITH HEPATIC ADENOMA. MARGINS OF RESECTION AND BACKGROUND LIVER CANNOT BE EVALUATED.
Case 40: LIVER, NEEDLE BIOPSY - HEPATOCELLULAR CARCINOMA, WELL DIFFERENTIATED, WITH FOCAL CLEAR CELL DIFFERENTIATION. NO BACKGROUND LIVER PRESENT FOR EVALUATION.
Case 41: LIVER, NEEDLE BIOPSY - HEPATOCELLULAR CARCINOMA, WELL DIFFERENTIATED, WITH FOCAL CLEAR CELL DIFFERENTIATION. NO BACKGROUND LIVER PRESENT FOR EVALUATION.
Case 42: LIVER, NEEDLE BIOPSY - IRREGULAR CIRRHOSIS WITH GIANT CELL HEPATITIS AND MINIMAL INFLAMMATORY ACTIVITY. FOCAL NONSPECIFIC COPPER ACCUMULATION IN HEPATOCYTES.
Case 43: PART 1: LIVER ALLOGRAFT, NEEDLE BIOPSY - MILD TO MODERATE ACUTE REJECTION WITH PROMINENT CENTRAL VENULITIS(RAI=3/9). HEPATITIS B VIRUS INFECTION WITH NUMEROUS GROUND GLASS HEPATOCYTES. MINIMAL VIRAL ASSOCIATED NECROINFLAMMATORY ACTIVITY. PART 2: LIVER ALLOGRAFT, NEEDLE BIOPSY - TREATED ACUTE CELLULAR REJECTION; GREATLY IMPROVED IN COMPARISON TO PREVIOUS BIOPSY (RAI=0/9). HEPATITIS B VIRUS INFECTION WITH MINIMAL VIRAL ASSOCIATED NECROINFLAMMATORY ACTIVITY. PERIPORTAL HEPATOCELLULAR SWELLING, INDICATIVE OF RECENT HIGH DOSE CORTICO-STEROID THERAPY. PART 3: LIVER ALLOGRAFT, NEEDLE BIOPSY - MILD ACUTE CELLULAR REJECTION, WITH PROMINENT CENTRAL VENULITIS (RAI=3/9) AND MILD PERIVENULAR FIBROSIS. MILD INTERFACE ACTIVITY SUGGESTIVE OF A LESSER COMPONENT OF CHRONIC HEPATITIS (See microscopic description). HEPATITIS B VIRAL INFECTION (See microscopic description).
Case 44: LIVER, NEEDLE BIOPSY - HISTOLOGIC CHANGES OF NODULAR REGENERATIVE HYPERPLASIA. PORTAL FIBROSIS AND GLYCOGENATED HEPATOCYTE NUCLEI.
Case 45: LIVER, NEEDLE BIOPSY - ACTIVE, PREDOMINANTLY MICRONODULAR CIRRHOSIS, MOST CONSISTENT WITH A "BILIARY" ETIOLOGY(see microscopic description).
Case 46: PART 1: ALLOGRAFT LIVER, NEEDLE BIOPSY - MODERATE ACUTE CELLULAR REJECTION WITH PROMINENT CENTRAL VENULITIS (RAI 2+2+2=6/9). NO PREVIOUS BIOPSIES AVAILABLE FOR COMPARISON. PART 2: ALLOGRAFT LIVER, NEEDLE BIOPSY - MILD ACUTE CELLULAR REJECTION WITH PROMINENT CENTRAL VENULITIS (RAI 2+1+2=5/9). SIMILAR OR SLIGHTLY IMPROVED IN COMPARISON TO PREVIOUS BIOPSY. FOCAL BILE DUCT LOSS IN FOUR OF FOURTEEN (4/14) PORTAL TRIADS.
Case 47: ALLOGRAFT LIVER, NEEDLE BIOPSY - PORTION OF LIVER WITH DENSE FIBROSIS AND CHRONIC INFLAMMATION (See comment).
Case 48: LIVER, NEEDLE BIOPSY - POORLY DIFFERENTIATED CARCINOMA WITH DESMOPLASTIC STROMA (see comment). BACKGROUND LIVER WITH HISTOLOGIC CHANGES INDICATIVE OF ADJACENT MASS LESION.
Case 49: LIVER, NEEDLE BIOPSY - MILD LYMPHOCYTIC PORTAL INFLAMMATION AND LOBULAR REACTIVITY. MILD MACROVESICULAR STEATOSIS.
Case 50: PART 1: NATIVE LIVER, NEEDLE BIOPSY - CHRONIC HEPATITIS WITH PORTAL FIBROSIS (see comment). PART 2: NATIVE LIVER, NEEDLE BIOPSY - LIVER WITH REDUCED NUMBERS OF BILE DUCTS, FOCAL DUCTULAR PROLIFERATION AND PERIPORTAL FIBROSIS, COMPATIBLE WITH THE CLINICAL HISTORY OF PRIMARY BILIARY CIRRHOSIS.
Case 51: LIVER, NEEDLE BIOPSY - MICRONODULAR CIRRHOSIS WITH LOSS OF INTRALOBULAR BILE DUCTS AND CHANGES OF CHRONIC CHOLESTASIS SUGGESTING BILIARY CIRRHOSIS (see comment). FOCAL DENSE PERIVENULAR FIBROSIS.
Case 52: ALLOGRAFT LIVER, NEEDLE BIOPSY- BILE DUCT CHANGES WITH DUCTULAR PROLIFERATION AND MIXED PORTAL INFLAMMATION (EXCLUDE BILE DUCT STRICTURE). CANALICULAR CHOLESTASIS, CHOLESTATIC ROSETTES, AND DIFFUSE HEPATOCYTE SWELLING (see diagnostic comment). MINIMAL MACROVESICULAR STEATOSIS.
Case 53: LIVER, PARTIAL RESECTION - WELL DIFFERENTIATED HEPATOCELLULAR CARCINOMA (see microscopic description).
Case 54: ALLOGRAFT LIVER, NEEDLE BIOPSY - NO EVIDENCE OF ACUTE REJECTION (RAI 0/9). CHRONIC HEPATITIS, VIRAL TYPE C BY HISTORY, MILDLY ACTIVE (MODIFIED HAI SCORE = 1+0+1+1=3/18). FOCAL MILD PORTAL FIBROSIS. MILD NODULAR REGENERATIVE HYPERPLASIA-TYPE CHANGES (see microscopic description).
Case 55: LIVER, NEEDLE BIOPSY- SEVERE, DIFFUSE, PREDOMINANTLY MACROVESICULAR STEATOSIS. REACTIVE PORTAL CHANGES INCLUDING DUCTULAR CHOLESTASIS.
Case 56: LIVER, NEEDLE BIOPSY (31 DAYS STATUS POST BONE MARROW TRANSPLANTATION) - MARKED CHOLESTASIS, CHOLANGIOLAR PROLIFERATION AND FOCAL HEPATOCYTE SWELLING, CONSISTENT WITH SEPSIS. NO DEFINITE EVIDENCE OF VENO-OCCLUSIVE DISEASE. A MINOR, LESSER COMPONENT OF GRAFT VERSUS HOST DISEASE CANNOT ABSOLUTELY BE EXCLUDED(see microscopic description).
Case 57: LIVER, NEEDLE BIOPSIES Parts 1 and 2- NON-SUPPURATIVE LYMPHOCYTIC DESTRUCTIVE CHOLANGITIS, MOST CONSISTENT WITH PRIMARY BILIARY CIRRHOSIS(See microscopic description).
Case 58: LIVER, INCISIONAL BIOPSIES - WELL DIFFERENTIATED HEPATOCELLULAR CARCINOMA. NO DEFINITE VASCULAR INVASION IDENTIFIED. BACKGROUND LIVER SHOWING MIXED CIRRHOSIS WITH MILD INFLAMMATORY ACTIVITY.
Case 59: LIVER, NEEDLE BIOPSY - OBSTRUCTIVE TYPE PORTAL TRACT CHANGES WITH PORTAL-PORTAL BILIARY FIBROSIS. MILD CANALICULAR CHOLESTASIS. KUPFFER CELL SIDEROSIS WITH 1+ HEPATOCELLULAR IRON ACCUMULATION.
Case 60: LIVER, NEEDLE BIOPSY - DUCTAL PROLIFERATION, MARKED CHOLESTASIS AND ACUTE CHOLANGITIS, MOST CONSISTENT WITH BILIARY TRACT OBSTRUCTION OR STRICTURING(See microscopic description).
Case 61: LIVER, NEEDLE BIOPSY - ACTIVE HEPATITIS, WITH AN PROMINENT LOBULAR COMPONENT AND FEATURES SUGGESTIVE OF A CHOLESTATIC VARIANT(MODIFIED HAI=1+0+3+1 =5/18), CONSISTENT WITH VIRAL TYPE C(See microscopic description). MILD PORTAL FIBROSIS(STAGE 1/6). NO PREVIOUS BIOPSY AVAILABLE FOR COMPARISON.
Case 62: ALLOGRAFT LIVER, NEEDLE BIOPSY - CHANGES SUGGESTIVE OF LARGE DUCT OBSTRUCTION OR STRICTURING. SPOTTY ACIDOPHILIC NECROSIS OF HEPATOCYTES (report of CMV stain to follow). MINIMAL TO NO EVIDENCE OF ACUTE REJECTION (RAI 1/9).
Case 63: LIVER, NEEDLE BIOPSY - MILDLY ACTIVE, MIXED IRREGULAR CIRRHOSIS (see microscopic description).
Case 64: LIVER ALLOGRAFT, NEEDLE BIOPSY- NO EVIDENCE OF ACUTE REJECTION (RAI = 0/9). MILD PANLOBULAR CONGESTION WITH FOCAL MINIMAL INTRALOBULAR REGENERATIVE CHANGES AND MILD CHOLANGIOLAR REACTIVITY(See microscopic description).
Case 65: LIVER, PARTIAL RESECTION (4377-97) - MYXOID MESENCHYMAL LESION, MOST CONSISTENT WITH MESENCHYMAL HAMARTOMA (see microscopic description).
Case 66: LIVER, BIOPSY - ACTIVE MICRONODULAR CIRRHOSIS WITH UNDERLYING STEATOHEPATITIS (See comment).
Case 67: LIVER, NEEDLE BIOPSY - CHRONIC HEPATITIS WITH MODERATE INFLAMMATORY ACTIVITY AND BRIDGING FIBROSIS. HISTOLOGIC FEATURES CONSISTENT WITH HEPATITIS C INFECTION.
Case 68: CHANGES CONSISTENT WITH PRIMARY BILIARY CIRRHOSIS (see microscopic description).
Case 69: LIVER, NEEDLE BIOPSY - EVOLVING CIRRHOSIS WITH MODERATE INFLAMMATORY ACTIVITY. NO SPECIFIC ETIOLOGIC CLUES IDENTIFIED.
Case 70: ALLOGRAFT LIVER, NEEDLE BIOPSY - TREATED ACUTE CELLULAR REJECTION, MARKEDLY IMPROVED IN COMPARISON TO PREVIOUS BIOPSY (RAI 3/9). RESIDUAL BILE DUCT DAMAGE AND ATROPHY/PYKNOSIS WITH BILE DUCT LOSS INVOLVING THREE OF EIGHT (3/8) PORTAL TRIADS, CONSISTENT WITH THE EARLIEST PHASES OF CHRONIC REJECTION(see microscopic description). MODERATE PORTAL FIBROSIS WITH FOCAL PORTAL-TO-CENTRAL BRIDGING AND EARLY REGENERATIVE NODULARITY, CONSISTENT WITH A BACKGROUND OF CHRONIC HEPATITIS C VIRUS INFECTION (see microscopic description).
Case 71: LIVER, NEEDLE BIOPSY -
PROMINENT BILE DUCTULAR PROLIFERATION AND ASSOCIATED PORTAL INFLAMMATION, CONSISTENT WITH LOW GRADE BILIARY OBSTRUCTION. PORTAL AND PERIPORTAL FIBROSIS.
Case 72: LIVER, NEEDLE BIOPSY - BILE DUCT INJURY AND LOSS IN FOUR OF EIGHT PORTAL TRACTS, ASSOCIATED WITH PORTAL TRACT ATROPHY. (see comment) MILD LOBULAR REACTIVITY. MINIMAL MACROVESICULAR STEATOSIS.
Case 73: ALLOGRAFT LIVER, NEEDLE BIOPSY - CHRONIC DUCT INJURY WITH CHOLESTASIS AND EARLY DUCT LOSS, CONSISTENT WITH EARLY CHRONIC REJECTION.
Case 74: PART 1: LIVER, HEPATECTOMY AND ORTHOTOPIC LIVER TRANSPLANTATION - CONFLUENT MULTILOBULAR AND BRIDGING NECROSIS, CONSISTENT WITH THE CLINICAL DIAGNOSIS OF FULMINANT HEPATIC FAILURE. NO SPECIFIC ETIOLOGIC CLUES IDENTIFIED. Part 2: ALLOGRAFT LIVER, NEEDLE BIOPSY - MILD ACUTE CELLULAR REJECTION. PART 2: Part 3: ALLOGRAFT LIVER, NEEDLE BIOPSY - MILD ACUTE CELLULAR REJECTION, PARTIALLY TREATED. MINOR IMPROVEMENT COMPARED TO PREVIOUS BIOPSY. PART 4: ALLOGRAFT LIVER, NEEDLE BIOPSY - CHRONIC BILE DUCT INJURY WITH INTERLOBULAR BILE DUCTS MISSING FROM SIX FROM THIRTEEN (6/13) PORTAL TRACTS, CONSISTENT WITH EARLY EVOLVING CHRONIC REJECTION. HE STAIN NOT REVIEWED; ONLY CONNECTIVE TISSUE STAINS PROVIDED. PART 5: ALLOGRAFT LIVER, NEEDLE BIOPSY - CHRONIC BILE DUCT INJURY WITH INTERLOBULAR BILE DUCTS MISSING FROM SEVEN OF SEVENTEEN (7/17) PORTAL TRACTS, CONSISTENT WITH EARLY EVOLVING CHRONIC REJECTION. MILD DIFFUSE HEPATOCYTE SWELLING. FOCAL INTRALOBULAR DUCT DILATATION WITH ASSOCIATED MIXED INFLAMMATORY REACTION.
Case 75: PART 1: ALLOGRAFT LIVER, NEEDLE BIOPSY (Part 1) PORTAL AND LOBULAR INFLAMMATION CONSISTENT WITH RECURRENCE OF CHRONIC HEPATITIS, VIRUS TYPE C INFECTION, WITH LOW-GRADE ACTIVITY (HAI=1+1+3+1=6/22). MINIMAL TO NO EVIDENCE OF ACUTE OR CHRONIC REJECTION. PART 2: ALLOGRAFT LIVER, NEEDLE BIOPSY (Part 2) - MILD LOBULAR DISARRAY, HEPATOCYTE SWELLING AND SPOTTY ACIDOPHILIC HEPATOCYTE NECROSIS(see microscopic description). MILD CENTRILOBULAR PIGMENT LADENED MACROPHAGE DEPOSITION.
Case 76: NATIVE LIVER, NEEDLE BIOPSY - SUSPICIOUS FOR MALIGNANCY.
Case 77: ALLOGRAFT LIVER, NEEDLE BIOPSY- INDETERMINATE FOR ACUTE REJECTION (RAI 1+1+0=2/9). CHANGES CONSISTENT WITH MODERATE TO SEVERE ISCHEMIC/PRESERVATION INJURY (see microscopic description).
Case 78: ALLOGRAFT LIVER, NEEDLE BIOPSY- INDETERMINATE FOR ACUTE REJECTION (RAI 1+1+0=2/9). CHANGES CONSISTENT WITH MODERATE TO SEVERE ISCHEMIC/PRESERVATION INJURY (see microscopic description).
Case 79: ALLOGRAFT LIVER, NEEDLE BIOPSY - MILD PORTAL AND LOBULAR INFLAMMATION; CLINICAL HISTORY OF HEPATITIS C INFECTION (See comment). FOCAL MACROVESICULAR STEATOSIS WITH MILD PERIPORTAL AND SINUSOIDAL FIBROSIS. FRAGMENT OF CARTILAGE WITH NO SIGNIFICANT PATHOLOGIC CHANGE.
Case 80: ALLOGRAFT LIVER, NEEDLE BIOPSY- RECURRENT HEPATITIS C, WITH MILD TO MODERATE INFLAMMATORY ACTIVITY, AND MILD PORTAL FIBROSIS (HAI = 10/22). FOCAL DUCT ATROPHY AND DUCT LOSS (2/16 PORTAL TRIADS); CHANGES INSUFFICIENT FOR THE DIAGNOSIS OF ACUTE REJECTION, BORDERLINE ACTIVITY, BANFF GRADE 0;(REJECTION ACTIVITY INDEX 1-2/9).
Case 81: LIVER, NEEDLE BIOPSY - MODERATELY WELL-DIFFERENTIATED ADENOCARCINOMA WITH APPARENT ANGIOLYMPHATIC INVASION, CONSISTENT WITH BILIARY TRACT PRIMARY. CHANGES INDICATIVE OF BILIARY TRACT OBSTRUCTION AND/OR STRICTURING.
Case 82: ALLOGRAFT LIVER, NEEDLE BIOPSY - MILD ACUTE CELLULAR REJECTION WITH PROMINENT BILE DUCT DAMAGE AND CENTRAL VENULITIS (RAI 4/9). DUCTULAR AND CHOLANGIOLAR PROLIFERATION WITH BILIARY EPITHELIAL CELL ATROPHY AND PYKNOSIS, SUGGESTIVE OF BILIARY TRACT OBSTRUCTION OR STRICTURING; BILIARY SLUDGE AND ISCHEMIC CHOLANGITIS SHOULD BE EXCLUDED. INCREASED DUCTAL DAMAGE AND CENTRILOBULAR HEPATOCELLULAR INFLAMMATION AND DROPOUT IN COMPARISON TO PREVIOUS BIOPSY (BY REPORT).
Case 83: LIVER, NEEDLE BIOPSY - CHANGES SUGGESTIVE OF THE EARLIEST PHASES OF CHRONIC REJECTION (See microscopic description). PORTAL FIBROSIS, FOCALLY BRIDGING, AND DUCTULAR PROLIFERATION CONSISTENT WITH THE HISTORY OF PREVIOUSLY DOCUMENTED RECURRENT PRIMARY BILIARY CIRRHOSIS.
Case 84: LIVER, NEEDLE BIOPSY - DENSE MONONUCLEAR PORTAL INFLAMMATION WITH SCATTERED EPITHELIOID GRANULOMAS AND MILD INTERFACE (PIECEMEAL) ACTIVITY. FOCAL LYMPHOCYTIC CHOLANGITIS AND BILE DUCTULAR PROLIFERATION WITH CHANGES OF CHRONIC CHOLESTASIS (see comment).
Case 85: LIVER, NEEDLE BIOPSY - SEVERAL FOCI OF MODERATELY DIFFERENTIATED HEPATOCELLULAR CARCINOMA. BACKGROUND LIVER SHOWING EXTENSIVE PARENCHYMAL COLLAPSE AND DENSE FIBROSIS WITH FLORID DUCTULAR PROLIFERATION.
Case 86: LIVER, NEEDLE BIOPSY - CHRONIC HEPATITIS WITH MODERATE INFLAMMATORY ACTIVITY, BRIDGING FIBROSIS, AND EARLY ARCHITECTURAL DISTORTION SUGGESTING DEVELOPING CIRRHOSIS (HAI=14/22). MILD MACROVESICULAR STEATOSIS AND SCATTERED GLYCOGENATED HEPATOCYTE NUCLEI.
Case 87: LIVER, NEEDLE BIOPSY - ADVANCED MACRONODULAR CIRRHOSIS WITH MINIMAL INFLAMMATORY ACTIVITY. PAS-POSITIVE CYTOPLASMIC GLOBULES, SUGGESTIVE OF ALPHA-1- ANTITRYPSIN DEFICIENCY (see comment). SCATTERED EPITHELIOID GRANULOMAS.
Case 88: LIVER, WEDGE BIOPSY - MIXED MACRONODULAR AND MICRONODULAR CIRRHOSIS WITH MILD INFLAMMATORY ACTIVITY AND FOCI OF FLORID, BUT REACTIVE, DUCTULAR PROLIFERATION. NO SPECIFIC ETIOLOGIC CLUES IDENTIFIED.
Case 89: LIVER, RESECTION - BENIGN BILIARY-TYPE CYST (See microscopic description). SURGICAL MARGINS FREE OF INVOLVEMENT. INSUFFICIENT BACKGROUND LIVER FOR ASSESSMENT.
Case 90: LIVER, NEEDLE BIOPSY - BENIGN FIBROMYXOID VASCULAR CONNECTIVE TISSUE, CONSISTENT WITH SCLEROSED HEMANGIOMA. NO EVIDENCE OF MALIGNANCY.
Case 91: LIVER, NEEDLE BIOPSY (8/20/97) - FRAGMENTED SPECIMEN WITH ARCHITECTURAL ALTERATIONS SUGGESTING EVOLVING CIRRHOSIS. BILIARY FIBROSIS WITH CHRONIC BILE DUCT INJURY AND CHANGES OF CHRONIC CHOLESTASIS (See comment).
Case 92: LIVER, NEEDLE BIOPSY - CHRONIC HEPATITIS WITH MILD TO MODERATE INFLAMMATORY ACTIVITY AND NO FIBROSIS (HAI 8/22). GLYCOGENATED HEPATOCYTE NUCLEI AND MINIMAL STEATOSIS.
Case 93: LIVER, NEEDLE BIOPSY - A.MODERATELY DIFFERENTIATED HEPATOCELLULAR CARCINOMA. B.CHRONIC HEPATITIS, CAUSE UNCERTAIN, WITH MILD INFLAMMATORY ACTIVITY, MACROVESICULAR STEATOSIS, AND PORTAL TO PORTAL BRIDGING FIBROSIS (See comment).
Case 94: LIVER, NEEDLE BIOPSY - A. ZONAL PERIVENULAR HEPATOCELLULAR DROPOUT, CONGESTION AND HEMORRHAGE, SUGGESTIVE OF AN ADVERSE DRUG REACTION OR HEPATOTOXIN. B. MILD TO FOCALLY MODERATE CHRONIC PORTAL INFLAMMATION WITH LOW-GRADE INTERFACE ACTIVITY; AUTOIMMUNE LIVER DISEASE AND CHRONIC VIRAL INFECTION SHOULD BE EXCLUDED (see microscopic description).
Case 95: LIVER, NEEDLE BIOPSY - SEVERE ACUTE HEPATITIS WITH CONFLUENT, BRIDGING AND MULTI-ACINAR HEPATOCELLULAR NECROSIS (see microscopic description).
Case 96: LIVER, NEEDLE BIOPSY - A. MARKED (3-4 ON A SCALE OF 0-4) PREDOMINANTLY HEPATOCELLULAR IRON DEPOSITION, MOST CONSISTENT WITH HEREDITARY HEMOCHROMATOSIS (see microscopic description). B. MILD TO MODERATE PORTAL FIBROSIS WITH MILD ARCHITECTURAL DISTORTION. C. MILD CHRONIC PORTAL TRACT INFLAMMATION WITH LOW GRADE INTERFACE ACTIVITY (see microscopic description).
Case 97: NATIVE LIVER, BIOPSY - A. ATROPHIC/DYSPLASTIC BILIARY EPITHELIAL CHANGES AND CENTRILOBULAR INFLAMMATION, HEMORRHAGE AND DROP OUT, MOST CONSISTENT WITH GRAFT-VERSUS-HOST DISEASE (see microscopic description). B. DUCTULAR PROLIFERATION AND BILIARY-TYPE FIBROSIS; CO-EXISTANT BILIARY TRACT OBSTRUCTION OR STRICTURING CANNOT BE EXCLUDED (See comment and microscopic description).
Case 98: NATIVE LIVER, NEEDLE BIOPSY - A. CHRONIC HEPATITIS, COMPATBLE WITH AUTOIMMUNE ETIOLOGY UNDER THERAPY, MILD TO MODERATELY ACTIVE WITH FOCAL LYMPHOCYTIC CHOLANGITIS. B. PORTAL-TO-PORTAL BRIDGING FIBROSIS WITH FOCAL NODULE FORMATION(see microscopic description). C. SUPERIMPOSED CMV HEPATITIS. D. PROMINENT CHOLESTASIS, MALLORY' S BODIES, INTRA-LOBULAR FOAM CELL CLUSTERS AND ACTIVE STEATOHEPATITIS(see microscopic description).
Case 99: NATIVE LIVER, WEDGE BIOPSY - A. PORTAL, PERIPORTAL AND LOBULAR INFLAMMATION WITH PROMINENT PLASMA CELL COMPONENT AND CHOLESTASIS; MOST CONSISTENT WITH PROLONGED HEPATITIS A VIRAL HEPATITIS(see microscopic description). B. MILD PORTAL FIBROSIS.
Case 100: LIVER, NEEDLE BIOPSY - A. GRANULOMATOUS PORTAL INFLAMMATION, WITH CHOLANGIOLAR PROLIFERATION, PERIPORTAL CHOLESTASIS, AND EARLY PORTAL TO PORTAL BRIDGING FIBROSIS. B. LOBULAR INFLAMMATION AND REGENERATIVE CHANGE, WITH FOCAL DUCT LOSS (3/17 DUCTS).
Case 101: NATIVE LIVER, NEEDLE BIOPSY - A. WELL DIFFERENTIATED HEPATOCELLULAR CARCINOMA. B. NO NON-NEOPLASTIC LIVER IDENTIFIED.
Case 102: Part 1: ALLOGRAFT LIVER, NEEDLE BIOPSY - A. CENTRAL LOBULAR HEPATOCELLULAR SWELLING, MILD DUCTULAR REACTION, AND MODERATE DEPOSITION OF CEROID PIGMENT/IRON IN KUPFFER CELLS AND MACROPHAGES; CONSISTENT WITH ONGOING RECOVERY FROM MODERATE ISCHEMIC/PRESERVATION INJURY (see Microscopic Description). B. NO ACUTE CELLULAR REJECTION (RAI:0/9). PART 2: ALLOGRAFT LIVER, NEEDLE BIOPSY - A. MILD LOBULAR INFLAMMATION AND SPOTTY NECROSIS CONSISTENT WITH THE LOBULAR PHASE OF RECURRENT HEPATITIS C VIRAL INFECTION. B. MILD ZONE 3 HEPATOCELLULAR SWELLING AND MILD TO MODERATE HEMOSIDERIN/CEROID PIGMENT DEPOSITION IN KUPFFER CELLS; CHANGES CONSISTENT WITH ONGOING RECOVERY FROM ISCHEMIC/PRESERVATION INJURY. 1. PRESERVATION/ISCHEMIC INJURY SIGNIFICANTLY IMPROVED OVER THAT OF THE PREVIOUS BIOPSY. C. NO ACUTE CELLULAR REJECTION (RAI: 0/9). PART 3: ALLOGRAFT LIVER, NEEDLE BIOPSY - A. MILD LOBULAR INFLAMMATION AND SPOTTY NECROSIS CONSISTENT WITH THE LOBULAR PHASE OF RECURRENT HEPATITIS C VIRAL INFECTION. 1. THE LEVEL OF HEPATITIC C VIRAL ACTIVITY IS OVERALL SIMILAR TO THAT SEEN IN THE PREVIOUS BIOPSY, THOUGH THE CURRENT BIOPSY SHOWS MILD CHOLESTASIS (see Microscopic Description). B. NO ACUTE CELLULAR REJECTION (RAI:0/9)
Case 103: LIVER ALLOGRAFT, NEEDLE BIOPSY - A. CHANGES MOST CONSISTENT WITH THE LOBULAR PHASE OF RECURRENT HEPATITIS C (SEE MICROSCOPIC DESCRIPTION). B. INDETERMINATE FOR ACUTE REJECTION (RAI = 2/9).
Case 104: LIVER ALLOGRAFT, NEEDLE BIOPSY - A. MILD ACUTE CELLULAR REJECTION WITH PERSISTENT CENTRAL VENULITIS AND FOCAL PERIVENULAR FIBROSIS. B. BACKGROUND OF CHRONIC HEPATITIS, CONSISTENT WITH VIRAL TYPE C, MINIMALLY ACTIVE.