The biopsy most likely represents subcapsular tissue. The overall process is suggestive of a cirrhotic pattern compatible with hepatitis C infection, consistent with the clinical history. However, the change may be focal and non-representative of the liver as a whole. Given the degree of fibroinflammatory change in this biopsy, comment regarding the presence or absence of rejection elsewhere is not possible. The inflammation, although dense, does not appear to have the atypia associated with post transplant lymphoproliferative disease.
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Liver Transplant Topics
The biopsy consists of a fragmented core of tissue with recognizable bile ducts and ductules, and rare hepatocytes. On one end of the specimen appears dense regular connective tissue, possibly capsular. Vessel and duct proliferation is noted throughout the remainder of the specimen, together with a moderately dense predominantly chronic inflammatory infiltrate. No atypical cells or mass lesions are appreciated. Bile ducts occasionally show slight disorientation of nuclear placement, but in general appear unremarkable.