Moderated by: Parmjeet S. Randhawa, MD, Lorraine C. Racusen, MD and Kim Solez, MD

Acute Allograft Rejection

• Overview of Acute Allograft Rejection
• Antibody mediated Rejection
• Borderline Changes
• Mild Acute Rejection
• Moderate Acute Rejection
• Severe Acute Rejection

Chronic Allograft Nephropathy

• Overview of Chronic Allograft Nephropathy
• Transplant Glomerulonephropathy
• Ischemic Glomerulonephropathy
• Chronic Interstitial Fibrosis and Tubular Atrophy
• Arteriosclerosis

Differential Diagnostic Considerations in the Allograft Biopsy

• Acute Tubular Necrosis
• Drug Induced Changes
  • Tubular and Myocyte Vacuolization
  • Striped Fibrosis
  • Microvascular Toxicity
• Recurrent Disease
  • Focal Segmental Glomerulonephritis
  • Membranous Glomerulonephritis
  • Membranoproliferative Glomerulonephritis
  • IgA Nephropathy
  • Diabetes Mellitus
• Acute Interstitial Nephritis
  • Polyoma Virus Infections
• Pre-Existing Disease
• Subcapsular Injury
• Pretransplant Acute Endothelial Injury
• Papillary Necrosis
• De Novo Glomerulonephritis
• Posttransplant Lymphoproliferative Disorder
• Other

• Renal Electronmicrographs
• Role of Donor Kidney Biopsies in Renal Transplantation
• Prediction of Creatinine Clearance from Clinical Parameters

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