Foci with >10 cells/tubular cross section, or the presence
of at least two areas of tubular basement membrane destruction accompanied by
i2/i3 inflammation and t2 tubulitis elsewhere in the biopsy.
Quantitative Criteria for Mononuclear Cell Interstitial Inflammation ("i")
Severe intimal arteritis in many arterial cross sections
and/or "transmural" arteritis, fibrinoid change and medial smooth muscle
necrosis, often with patchy infarction and interstitial hemorrhage
Quantitative Criteria for Allograft Glomerulopathy ("cg")
Vascular narrowing of up to 25% lumenal area by
fibrointimal thickening of arteries ± breach of internal elastic lamina
or presence of foam cells or occasional mononuclear cells
Severe vascular changes with >50% narrowing of
vascular lumenal area
References
Solez K, et al. International standardization of criteria for the histologic diagnosis of renal allograft rejection: The Banff working classification of kidney transplantation.
Kidney Int 1993;44(2):411-22.
Solez K, et al. Report of the third Banff conference on allograft pathology (July 20-24, 1995) on classification and lesion scoring in
renal allograft pathology.
Trans Proc 1996;28(1):441-4.
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