Foci with >10 cells/tubular cross section, or the presence
of at least two areas of tubular basement membrane destruction accompanied by
i2/i3 inflammation and t2 tubulitis elsewhere in the biopsy.  WS
Quantitative Criteria for Mononuclear Cell Interstitial Inflammation ("i")
Vascular narrowing of up to 25% lumenal area by fibrointimal thickening of arteries ± breach of internal elastic lamina or presence of foam cells or occasional mononuclear cells*
Severe vascular changes with >50% narrowing of vascular lumenal area*
* in most severely affected vessel. Note if lesions characteristic of chronic rejection (elastica breaks, inflammatory cells in fibrosis, formation of neointima) are seen
Quantitative Criteria for Mesangial Matrix Increase ("mm")*
>50% of nonsclerotic glomeruli affected (at least moderate
matrix increase)
* The threshold criterion for the moderately increased "mm" is the expanded mesangial interspace between adjacent capillaries. If the width of the
interspace exceeds two mesangial cells on the average in at least two glomerular lobules the "mm" is moderately increased
References
Solez K, et al. International standardization of criteria
for the histologic diagnosis of renal allograft rejection: The Banff
working classification of kidney transplant pathology.
Kidney Int 1993;44(2):411-22.
Solez K,
et al. Report of the third Banff conference on allograft
pathology (July 20-24, 1995) on classification and lesion scoring in
renal allograft pathology.
Trans Proc 1996;28(1):441-4.
Racusen L, et al. The Banff 97 working classification of renal allograft pathology. Kidney Int 1999;55:713-723
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