Other autoimmune disease (patient or first-degree relative)
Absent
Present
Blood transfusion or drugs
Yes
No
Alcohol (male)
80 gm/day
50-80 gm/day
35-50 gm/day
<35 gm/day
Alcohol (female)
60 gm/day
40-60 gm/day
25-40 gm/day
<25 gm/day
IgM anti HAV
Present
Absent
HBsAg or IgM anti HBc
Present
Absent
HCV RNA
Present
Absent
Anti-HCV and/or RIBA
Present
Absent
Other viral markers
Present
Absent
No viral markers
No viral markers
HLA B8 DR3 or DR4
Absent
Present
IgG, gamma glob, or globulin
<1x normal
1-1.5x normal
1.5-2x normal
2x+ normal
Alk phos:ALT
3
ANA, SMA, or LKM1 (adults)
<1:40
1:40
1:80
1:80
ANA or LKM1 (children)
<1:10
1:10-20
1:20
SMA (children)
<1:20
1:20
1:20
Other markers
Present
AMA
Present
Absent
Histology
Incompatible bile duct changes
Mild bile duct changes
Frequent plasma cells, rosettes (1 each)
Bridging necrosis
Piecemeal necrosis, lobular hepatitis, and
bridging necrosis
Response to therapy
No response
Partial response or failure
Complete response
Relapse
Interpretation of scores: An aggregate score greater than 15 prior to therapy constitutes
a definite diagnosis of AIH. A score of 10-15 is interpreted as probable AIH. A score greater than 17 following therapy is considered positive,
and a score of 12-17 after therapy is considered probable, for the diagnosis of AIH.
