Posttransplant Neoplasia

PT-LPD Classification of 1995 (Knowles et al.)
Category Histopathology Clonal Status Oncogene or Tumor Suppressor Gene Changes
1 Plasma cell hyperplasia Polyclonal, occasional faint clone No
2 Polymorphic B cell hyperplasia or Polymorphic B cell lymphoma Monoclonal No
3 Pleomorphic immunoblastic lymphoma, plasmacytoid immunoblastoid lymphoma, or multiple myeloma Monoclonal Yes
Note: Observed molecular alterations in Category 3 included rearrangement of c-myc, mutation of N-ras and mutation of p53 in individual cases.

  • Knowles DM, Cesarman E, Chadburn A, Frizzera G, Chen J, Rose EA, Michler RE. Correlative morphologic and molecular genetic analysis demonstrates three distinct categories of posttransplant lymphoproliferative disorders. Blood 85:552-565,1995

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