Inclusion bodies typical of either herpes simplex or
varicella-zoster virus infection may not always be detected in the biopsy. When
present, they are most often located at the edge of the lesions in the rim of
viable cells at the edge. However, if one suspects either of these infections
the diagnosis should be immediately conveyed to the clinical physicians, even if
the pathologist is not 100 percent certain of the diagnosis. Untreated, either
of these infections involving the liver allograft can be rapidly fatal.