Figure 2.
Severe bile duct(BD) damage is the most prominent feature of the early phase
of chronic rejection. It is characterized by eosinophilic transformation of
the cytoplasm and uneven nuclear spacing. Nuclear enlargement and irregularity
similar to that seen in bile epithelial cell dysplasia can also be seen. The
severe duct damage is seen in more than an occasional bile duct and is
invariably associated with markedly increased serum levels of g-glutamyl
transpeptidase.
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