This section was taken from a presensitized recipient,
24 hours after transplantation. The titer of preformed
antibodies was high enough to affect the rejection
process, but not so high as to cause immediate graft
failure. Note that the sinusoids are now open and that
the Kupffer's cells contain numerous phagosomes, some
of which also show platelet granules and other breakdown
products. Compare this
image to the image captured 10 minutes
after transplantation. This illustrates at least
one of the mechanisms used by the liver to protect
itself from the effects of preformed antibody injury.
Please mail comments, corrections or suggestions to the
TPIS
administration at the UPMC.