Histologic findings in biopsies from patients with a peripancreatic abscess should be differentiated from features of rejection. Characteristically samples from patients with intra-abdominal infections show young fibroblastic proliferation with accentuation of the septal areas. The anastomosing fibrous bands give to the biopsy a "cirrhotic"
appearance. There is always significant mixed inflammation in the fibrous tissue with mild "spillage" into the periphery of the acinar lobules. Although the inflammation is predominantly lymphoid, eosinophils and neutrophils are often present. Venous endotheliitis is not prominent. In typical cases the diagnosis is easily made however, in some cases it is impossible to determine with absolute certainty if the inflammation is related only to the infection or if there is concurrent acute rejection.