Atherosclerotic disease in the donor is also likely a contributing factor to the
development of GVD. This section of a coronary artery was obtained at autopsy
from a heart graft that failed 6 days after transplantation because of rejection.
Although there is no endothelial inflammation in this artery, there
is blastic transformation of lymphocytes in the shoulder region of the
atherosclerotic plaque(arrow) that was likely a donor disease.