|
HISTOLOGY ACTIVITY INDEX (HAI - Knodell Score)
|
| Periportal ± Bridging Necrosis |
Score |
Intralobular Degeneration and Focal Necrosis |
Score |
Portal Inflammation |
Score |
Fibrosis |
Score |
| None |
0 |
None |
0 |
No portal inflammation |
0 |
No fibrosis |
0 |
| Mild piecemeal necrosis |
1 |
Mild (acidophilic bodies, ballooning
degeneration and/or scattered foci of hepatocellular necrosis
in 1/3 of lobules or nodules) |
1 |
Mild (sprinkling of inflammatory
cells in <1/3 of portal tracts) |
1 |
Fibrous portal expansion |
1 |
| Moderate piecemeal necrosis (involves
<50% of the circumference of most portal tracts) |
3 |
Moderate (involvement of 1/3-2/3
of lobules or nodules) |
3 |
Moderate (increased inflammatory cells
in 1/3-2/3 of portal tracts) |
3 |
Bridging Fibrosis (portal-portal or
portal-central linkage) |
3 |
| Marked piecemeal necrosis (involves
>50% of the circumference of most portal tracts) |
4 |
Marked (involvement of >2/3
of lobules or nodules) |
4 |
Marked (dense packing of inflammatory cells
in >2/3 of portal tracts) |
4 |
Cirrhosis |
4 |
| Moderate piecemeal necrosis plus
bridging necrosis |
5 |
Reference
Knodell RG, et al. Formulation
and Application of a Numerical Scoring System for Assessing Histological
Activity in Asymptomatic Chronic Active Hepatitis. Hepatology
1981;1(5):431-5
|
| Marked piecemeal necrosis plus
bridging necrosis |
6 |
| Multilobular necrosis |
10 |
|
Total HAI (Knodell Score) = __/22
|
