Moderated by: A. Jake Demetris, MD

Role of the Pathologist in Liver Transplantation

Approach to Tissue Specimens

• Pretransplant recipient liver biopsies
  • Hepatic Iron Index
• Native Hepatectomy Specimens
• Failed Allografts
• Post-transplant needle allograft biopsies

Evaluation of the Donor Liver

• Frozen sections
• Backtable biopsies

Causes of Liver Allograft Dysfunction

• Preservation Injury
• Vascular Thrombosis
• Biliary Tract Complications
• Rejection
  • Humoral
  • Acute(cellular)
    • Grading
  • Chronic(ductopenic)

Bacterial and Fungal Infections

Viral Infections

• Hepatitic Viruses
  • Acute and Chronic Viral Hepatitis, Type B
  • Fibrosing Cholestatic Hepatitis
  • Acute and Chronic Hepatitis, Type C
• Opportunistic Viruses
  • Cytomegalovirus
  • Epstein-Barr virus
  • Herpes Simplex/Varicella Zoster
  • Adenovirus

Recurrence of the Original Disease

• Neoplasia
• Metabolic Diseases
• Chronic Viral infections
• Autoimmune Disease

Allograft Pathology Related to Systemic Disorders

Macroscopic Liver Pathology Collection

Underwritten By

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