Overproduction of the B virus is thought to be directly cytopathy in some
liver allograft recipients, who develop this type of liver injury. The right
side of the photomicrograph shows marked hepatocyte swelling and degeneration in
the centrilobular zones with central-to-central and focal portal-to-central
bridging collapse. The left side of the photomicrograph shows the HBcAg stain
on the same specimen. Note the co-localization of the nuclear and cytoplasmic
HBcAg to the degenerating hepatocytes.