Figure 2. This renal allograft biopsy showed virtually all glomeruli to contain fibrin thrombi. Clinically, the patient had disseminated intravascular coagulation(DIC) for which no obvious cause was found. The patient responded to discontinuation of cyclosporine, and initiation of a tacrolimus based immunosuppressive regimen. Similar cases of putative tacrolimus induced DIC are also reported.

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