Heart Allograft Biopsy Interpretation

Preservation Injury Preservation Injury Preservation Injury Preservation Injury Preservation Injury Preservation Injury

Preservation Injury and Previous Biopsy Sites

Preservation or ischemia/reperfusion injury is seen early after transplantation and is characterized by areas of ischemic myocyte necrosis and/or variable areas of myocyte dropout. This necrotic/dropout zones are usually associated with mild neutrophilic or no inflammation, in contrast to the mononuclear and eosinophilic infiltrate that commonly signals the onset of acute cellular rejection.

Sampling of previous biopsy sites is also common early after transplantation. Common features include partially organized fibrin masses, mildly inflamed granulation tissue, iron or ceroid-ladened macrophages and disorganization of cardiac myocytes at the base of the lesion.

Last Modified: Mon Aug 24 8:00:00 EDT 2009