PTLDClass1995

PT-LPD Classification of 1995 (Knowles et al.)

Category Histopathology Clonal Status Oncogene or Tumor Suppressor Gene Changes

1 Plasma cell hyperplasia Polyclonal, occasional faint clone No

2 Polymorphic B cell hyperplasia or Polymorphic B cell lymphoma Monoclonal No

3 Pleomorphic immunoblastic lymphoma, plasmacytoid immunoblastoid lymphoma, or multiple myeloma Monoclonal Yes

Note: Observed molecular alterations in Category 3 included rearrangement of c-myc, mutation of N-ras and mutation of p53 in individual cases.

PT-LPD Classification of 1995 (Knowles et al.)
Category	Histopathology	Clonal Status	Oncogene or Tumor Suppressor Gene Changes
1	Plasma cell hyperplasia	Polyclonal, occasional faint clone	No
2	Polymorphic B cell hyperplasia or Polymorphic B cell lymphoma	Monoclonal	No
3	Pleomorphic immunoblastic lymphoma, plasmacytoid immunoblastoid lymphoma, or multiple myeloma	Monoclonal	Yes
Note: Observed molecular alterations in Category 3 included rearrangement of c-myc, mutation of N-ras and mutation of p53 in individual cases.

Reference

Knowles DM, Cesarman E, Chadburn A, Frizzera G, Chen J, Rose EA, Michler RE. Correlative morphologic and molecular genetic analysis demonstrates three distinct categories of posttransplant lymphoproliferative disorders. Blood 85:552-565,1995

Please mail comments, corrections or suggestions to the TPIS administration at the UPMC.

[FRAMES] [NO FRAMES]