Mild Acute Rejection

Mild acute cardiac allograft rejection is characterized by predominantly mononuclear perivascular and/or interstitial inflammation, that is generally mild, and not associated with myocyte necrosis. Early after transplantation, the mononuclear cells may be intermixed with fewer eosinophils and neutrophils. The key features distinguishing mild, or IHLTS Grade 1 rejection from moderate, or Grade 2 or 3 rejection, are the severity of the infiltrate and the presence of myocyte damage.

University of Pittsburgh. All rights reserved. Unauthorized redistribution prohibited.