Liver Allograft - Case 41

<HTML>  <HEAD><title>Consult Report - Case 41</title></HEAD> <body bgcolor=#ffffff link="darkblue" vlink="006666"> <IMG SRC="/tpis/icons/purpball.gif"><i> Contributed by Anthony Demetris, M.D.</A></i> <HR> <b>PATIENT HISTORY:</b> Per referral letter, the patient is a 57-year-old male. (These slides are in follow-up to the biopsies that were sent previously.) Since the time of the biopsies, the patient has progressed to irreversible liver failure. He was listed for retransplantation which was performed on 3/26/97. The explanted liver weighed 2089 grams and showed no focal lesions. The parenchyma was olive brown with patchy areas of dark red hemorrhage in a central lobular pattern. The microscopic sections demonstrate a paucity of bile ducts in the interlobular portal tracts. Foam cell atheropathy is present only focally. The more interesting finding is the presence of ulcerating endothelialitis both in the portal and central veins. In some areas, this is associated with small fibrin clots. Review of outside material. <hr> <a name="final"></a> <H4>Final Diagnosis (Case 41) [D1734-97]</H4> FAILED LIVER ALLOGRAFT, HEPATIC RETRANSPLANTATION PROCEDURE -<BR> <ol type=A> <li>FOAM CELL OBLITERATIVE ARTERIOPATHY WITH ACTIVE LYMPHOCYTIC ARTERITIS, BILE DUCT LOSS, CONGESTION, HEMORRHAGE AND MARKED CHOLESTASIS, ALL INDICATIVE OF CHRONIC REJECTION, WHICH LIKELY EVOLVED FROM ACUTE REJECTION (see microscopic description). <li>(stains for hepatitis B core and surface antigens are suggested.) </ol><p> <i><b>Previous Biopsies on this Patient:</b></i><br> <a href="/tpislibrary/casedata/H00055/" target="pages"<B>[D982-97]</B></a><BR> <a href="/tpislibrary/casedata/H00056/" target="pages"<B>[D808-97]</B></a><p> <i><b>TPIS Related Resources:</b></i><br> <a href="/tpislibrary/schema/BanffRej.html">Liver Allograft Rejection Grading</a><br> <a href="/tpislibrary/liver/index.html">Liver Transplant Topics</a><p> <a name="gross"></a> <hr><H4>Gross Description - Case 41 [D1734-97]</H4> The specimen consists of five (5) consult slides labeled D1734-97. No surgical pathology report is received with the specimen. <p> <a name="micro"></a> <HR><H4>Microscopic Description - Case 41 [D1734-97]</H4> <A HREF="/tpis/images/H00066a.jpg"><IMG SRC="/tpis/images/tnails/H00066a.jpg" width=133 height=100></a> <A HREF="/tpis/images/H00066b.jpg"><IMG SRC="/tpis/images/tnails/H00066b.jpg" width=133 height=100></a> <A HREF="/tpis/images/H00066c.jpg"><IMG SRC="/tpis/images/tnails/H00066c.jpg" width=133 height=100></a> <A HREF="/tpis/images/H00066d.jpg"><IMG SRC="/tpis/images/tnails/H00066d.jpg" width=133 height=100></a> <A HREF="/tpis/images/H00066e.jpg"><IMG SRC="/tpis/images/tnails/H00066e.jpg" width=133 height=100></a> <A HREF="/tpis/images/H00066f.jpg"><IMG SRC="/tpis/images/tnails/H00066f.jpg" width=133 height=100></a> <A HREF="/tpis/images/H00066g.jpg"><IMG SRC="/tpis/images/tnails/H00066g.jpg" width=133 height=100></a> <P> Sections through the hilum of the liver reveal large areas of fibrosis in the hilar connective tissue and mild mononuclear inflammation. There is also perineural edema and depletion and scarring of a hilar lymph node. In addition, there is focal foam cell obliterative arteriopathy and a superimposed lymphocytic arterial intimal inflammatory cell infiltrate, with marked endothelial cell hypertrophy(activation) and focal degeneration of medial myocytes. A small cuff of smaller adventitial macrophages are also seen in the affected vessels.<P> Throughout the parenchyma, the normal lobular architecture is slightly distorted because of mild portal expansion and areas of perivenular hepatocyte dropout, centrilobular congestion and hemorrhage. Loss of small bile ducts variably affects from about 30% to 60% of a random sampling of portal triads. In addition, there is marked eosinophilic transformation, uneven spacing and nuclear enlargement in the remaining ductal epithelial cells and collagenization of the portal tract connective tissue.<P> There is also marked centrilobular hepatocellular swelling, hepatocanalicular cholestasis, venular endothelial hypertrophy and moderate perivenular fibrosis. Intralobular foam cell clusters are also seen. No definite ground glass cells are detected, but special stains for Hepatitis B core and surface antigens should be used to exclude recurrent infection.<P> Overall, the histopathological changes are consistent with chronic liver allograft rejection, which appears to have evolved from acute rejection. This contention is based on the obliterative arteriopathy, the active lymphocytic intimal inflammation and the bile duct loss and atrophy.<P>  <hr> <font size=3> Please mail comments, corrections or suggestions to the <a href="mailto:harperth@upmc.edu"> <i>TPIS administration</i></a> at the UPMC.<p> This page and its contents are Copyright © 1996, 1997 <A HREF="http://www.upmc.com/Pages/default.aspx">University of Pittsburgh</a>. All rights reserved. Unauthorized redistribution prohibited.<p> </body> </html>