Liver Transplantation

Grading of Acute Liver Allograft Rejection
Global assessment of rejection grade made on a review of the biopsy and after the diagnosis of rejection has been established.
Global Assessment* Criteria
Indeterminate Portal inflammatory infiltrate that fails to meet the criteria for the diagnosis of acute rejection (see reference below)
Mild Rejection infiltrate in a minority of the triads, that is generally mild, and confined within the portal spaces
Moderate Rejection infiltrate, expanding most or all of the triads
Severe As above for moderate, with spillover into periportal areas and moderate to severe perivenular inflammation that extends into the hepatic parenchyma and is associated with perivenular hepatocyte necrosis
* Verbal description of mild, moderate or severe acute rejection could also be labeled as Grade I,II and III, respectively.
Reference Anonymous. Banff Schema for Grading Liver Allograft Rejection: An International Consensus Document. Hepatology 1997;25(3):658-63.

University of Pittsburgh.