| Grading of Acute Liver Allograft Rejection | |
|---|---|
| Global assessment of rejection grade made on a review of the biopsy and after the diagnosis of rejection has been established. | |
| Global Assessment* | Criteria |
| Indeterminate | Portal inflammatory infiltrate that fails to meet the criteria for the diagnosis of acute rejection (see reference below) |
| Mild | Rejection infiltrate in a minority of the triads, that is generally mild, and confined within the portal spaces |
| Moderate | Rejection infiltrate, expanding most or all of the triads |
| Severe | As above for moderate, with spillover into periportal areas and moderate to severe perivenular inflammation that extends into the hepatic parenchyma and is associated with perivenular hepatocyte necrosis |
| * Verbal description of mild, moderate or severe acute rejection could also be labeled as Grade I,II and III, respectively. | |
| Reference Anonymous. Banff Schema for Grading Liver Allograft Rejection: An International Consensus Document. Hepatology 1997;25(3):658-63. | |