The inflammatory infiltrate comprises both CD4+ (left) and CD8+ T-cells (right), as demonstrated by appropriate immunostains. These stains are helpful in demonstrating the character of the lymphocytes, but they are not generally useful in distinguishing acute rejection from other differential diagnostic considerations. Note that the CD8+ cells are the predominant cell within the crypt epithelium, reflecting the CD8+ nature of normal intraepithelial lymphocytes.