Figure 4. In contrast to cold preservation, which preferentially damages the sinusoidal endothelium, a warm ischemic insult more selectively damages the hepatocytes. In this photomicrograph, note the presence of centrilobular microvesicular steatosis, which is a fairly common finding in liver allograft biopsies in the peri-operative period. It usually signals a warm ischemic insult, but can also be seen with injuries related to drugs and toxins.

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