Figure 4. Bile ductular proliferation at the interface zone is typically seen in fibrosing cholestatic hepatitis. The CK19 stain in this case nicely highlights the neocholangioles present in zone 1. These ductules are usually surrounded by a mild neutrophilic exudate. In contrast to viral hepatitis in non-immunosuppressed patients, the portal mononuclear infiltrate is usually quite mild in fibrosing cholestatic hepatitis.

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