Figure 6. Grading of acute allograft rejection - inflammation of undetermined significance (Grade I). Focal mononuclear (lympho-plasmacytic) inflammation in septa, with questionable cuffing of part of a blood vessel. The acini are not inflamed. This type of changes may be seen rarely in protocol biopsies from patients with normal allograft function. Occasionally biopsies showing these changes are followed by a biopsy proven rejection episode (?sampling).

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