Heart Allograft Biopsy Interpretation

Figure 3. Compared to other solid organ allografts, Toxoplasmosis gondii is a parasitic infection that is more common in heart allograft biopsies than in liver or kidney sample. This is likely related to the cardiac myocytes serving as a site of latency. In the example shown above, there is no significant inflammation associated with the infected cell(arrow). A higher magnification shows in greater detail the small basophilic to amphophilic tachyzoites present in the myocyte(inset, upper left). Immunoperoxidase staining for Toxoplasmosis can be used to further substantiate the diagnosis(inset, lower left).

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Last Modified: Mon Aug 24 8:00:00 EDT 2009