CHAPTER 9

REFERENCES

1. Ishak KG: Hepatic morphology in the inherited metabolic diseases. Sem Liver Dis 6: 246-258, 1986.

2. Phillips MJ, Poucell S, Patterson J, Valencia P: Metabolic liver disease. In: The Liver: An Atlas and Text of Ultrastructural Pathology. New York, 1987, Raven Press. pp 239-391.

IRON ACCUMULATION

3. Adams PC: Hepatic iron in hemochromatosis. Dig Dis Sci 35: 690-692, 1990.

4. Adams PC: Intrafamilial variation in hereditary hemochromatosis. Dig Dig Sci 37: 361-363, 1992.

5. Adams PC, Ghent CN, Grant DR, et al: Transplantation of a donor liver with haemochromatosis: evidence against an inherited intrahepatic defect. Gut 32: 1082-1083, 1991.

6. Adams PC, Halliday JW, Powell LW: Early diagnosis and treatment of hemochromatosis. Adv Intern Med 34: 111-126, 1989.

7. Adams PC, Kertesz AE, Valberg LS: Clinical presentation of hemochromatosis: A changing scene. Am J Med 90: 445-449, 1991.

8. Adams PC, Speechley M, Kertesz AE: Long-term survival analysis in hereditary hemochromatosis. Gastroenterology 101: 368-372, 1991.

9. Ali M, Fayemi AO, Rigolosi R, et al: Hemosiderosis in hemodialysis patients. An autopsy study of 50 cases. JAMA 244: 343-345, 1980.

10. Bacon BR, Britton RS: The pathology of hepatic iron overload: A free radical-mediated process? Hepatology 11: 127-137, 1990.

11. Bardadin KA, Scheuer PJ: Endothelial cell changes in acute hepatitis. A light and electron microscopic study. J Pathol 144: 213-220, 1984.

12. Barnard JA III, Manci E: Idiopathic neonatal iron-storage disease. Gastroenterology 101: 1420-1427, 1991.

13. Barrow R, Grace ND, Sherwood G, Powell LW: Iron overload complicating sideroblastic anemia -- Is the gene for hemochromatosis responsible? Gastroenterology 96: 1204-1206, 1989.

14. Barry M: Liver iron concentration, stainable iron, and total body storage iron. Gut 15: 411-415, 1974.

15. Bassett ML, Halliday JW, Ferris RA, Powell LW: Diagnosis of hemochromatosis in young subjects: Predictive accuracy of biochemical screening tests. Gastroenterology 87: 628-633, 1984.

16. Bassett ML, Halliday JW, Powell LW: Value of hepatic iron measurements in early hemochromatosis and determination of the critical iron level associated with fibrosis. Hepatology 6: 24-29, 1986.

17. Blisard KS, Bartow SA: Neonatal hemochromatosis. Hum Pathol 17: 376-383, 1986.

18. Blumberg RS, Chopra S, Ibrahim R, et al: Primary hepatocellular carcinoma in idiopathic hemochromatosis after reversal of cirrhosis. Gastroenterology 95: 1399-1402, 1988.

19. Bodenheimer HC, Thayer WR: Hemochromatosis associated with cimetidine therapy? J Clin Gastroenterol 3: 83-85, 1981.

20. Bonkovsky HL, Slaker DP, Bills EB, Wolf DC: Usefulness and limitations of laboratory and hepatic imaging studies in iron-storage disease. Gastroenterology 99: 1079-1091, 1990.

21. Bothwell TH, Abrahams C, Bradlow BA, Charlton RW: Idiopathic and Bantu hemochromatosis. Comparative histological study. Arch Pathol 79: 163-168, 1965.

22. Brissot P, Bourel M, Herry D, et al: Assessment of liver iron content in 271 patients: A reevaluation of direct and indirect methods. Gastroenterology 80: 557-565, 1981.

23. Cartwright GE, Edwards CQ, Kravitz K, et al: Hereditary hemochromatosis. Phenotypic expression of the disease. N Engl J Med 301: 175-179, 1979.

24. Cartwright GE, Edwards CQ, Skolnick MH, et al: Association of HLA-linked hemochromatosis with idiopathic refractory sideroblastic anemia. J Clin Invest 65: 989-992, 1980.

25. Chapman RW, Morgan MY, Laulicht M, et al: Hepatic iron stores and markers of iron overload in alcoholics and patients with idiopathic hemochromatosis. Dig Dis Sci 27: 909-916, 1982.

26. Conn HO: Portacaval anastomosis and hepatic hemosiderin deposition: A prospective, controlled investigation. Gastroenterology 62: 61-72, 1972.

27. Conte D, Piperno A, Mandelli C, et al: Clinical, biochemical and histological features of primary hemochromatosis: a report of 67 cases. Liver 6: 310-315, 1986.

28. Dadone MM, Kushner JP, Edwards CQ, et al: Hereditary hemochromatosis. Analysis of laboratory expression of the disease by genotype in 18 pedigrees. Am J Clin Pathol 78: 196-207, 1982.

29. Dalhøj J, Kiaer H, Wiggers P, et al: Iron storage disease in parents and sibs of infants with neonatal hemochromatosis: 30-year follow-up. Am J Med Gen 37: 342-345, 1990.

30. Deugnier YM, Guyader D, Crantock L, et al: Primary liver cancer in genetic hemochromatosis: A clinical, pathological, and pathogenetic study of 54 cases. Gastroenterology 104: 228-234, 1993.

31. Deugnier YM, Loréal O, Turlin B, et al: Liver pathology in genetic hemochromatosis: A review of 135 homozygous cases and their bioclinical correlations. Gastroenterology 102: 2050-2059, 1992.

32. Deugnier Y, Margules S, Brissot P, et al: Comparative study between biochemical and histological methods and image analysis in liver iron overload. J Clin Pathol 35: 45-51, 1982.

33. Deugnier YM, Turlin B, Powell LW, et al: Differentiation between heterozygotes and homozygotes in genetic hemochromatosis by means of a histological hepatic iron index: A study of 192 cases. Hepatology 17: 30-34, 1993.

34. Edwards CQ, Carroll M, Bray P, Cartwright GE: Hereditary hemochromatosis. Diagnosis in sibling and children. N Engl J Med 297: 7-13, 1977.

35. Edwards CQ, Cartwright GE, Skolnick MH, Amos DB: Homozygosity for hemochromatosis: Clinical manifestations. Ann Intern Med 93: 519-525, 1980.

36. Edwards CQ, Dadone MM, Skolnick MH, Kushner JP: Hereditary hemochromatosis. Clin Haematol 11: 411-435, 1982.

37. Edwards CQ, Griffen LM, Goldgar D, et al: Prevalence of hemochromatosis among 11,065 presumably healthy blood donors. N Engl J Med 318: 1355-1362, 1988.

38. Edwards CQ, Skolnick MH, Kushner JP: Hereditary hemochromatosis: Contributions of genetic analysis. Prog Hematol 12: 43-71, 1981.

39. Escobar GJ, Heyman MB, Smith WB, Thaler MM: Primary hemochromatosis in childhood. Pediatrics 80: 549-554, 1987.

40. Fellows IW, Stewart M, Jeffcoate WJ, et al: Hepatocellular carcinoma in primary haemochromatosis in the absence of cirrhosis. Gut 29: 1603-1606, 1988.

41. Finch CA, Huebers H: Perspectives in iron metabolism. N Engl J Med 306: 1520-1528, 1982.

42. Gollan JL: Diagnosis of hemochromatosis. Gastroenterology 84: 418-421, 1983.

43. Gordeuk VR, Bacon BR, Brittenham GM: Iron overload: Causes and consequences. Ann Rev Nutr 7: 485-508, 1987.

44. Gordeuk VR, Boyd RD, Brittenham GM: Dietary iron overload persists in rural sub-Saharan Africa. Lancet 1: 1310-1313, 1986.

45. Gordeuk V, Mukiibi J, Hasstedt SJ, et al: Iron overload in Africa. Interaction between a gene and dietary iron content. N Engl J Med 326: 95-100, 1992.

46. Green P, Eviatar JM, Sirota P, Avidor I: Secondary hemochromatosis due to prolonged iron ingestion. Isr J Med Sci 25: 199-201, 1989.

47. Haddy TB, Castro OL, Rana SR: Hereditary hemochromatosis in children, adolescents, and young adults. Am J Pediatr Hematol Oncol 10: 23-34, 1988.

48. Hakim RM, Stivelman JC, Schulman G, et al: Iron overload and mobilizatin in long-term hemodialysis patients. Am J Kidney Dis 10: 293-299, 1987.

49. Halliday JW, Powell LW: Iron overload. Semin Hematol 19: 42-53, 1982.

50. Hardy L, Hansen JL, Kushner JP, Knisely AS: Neonatal hemochromatosis. Genetic analysis of transferrin-receptor, H-apoferritin, and L-apoferritin loci and of the human leukocyte antigen class I region. Am J Pathol 137: 149-153, 1990.

51. Hennigar GR, Greene WB, Walker EM, deSaussure C: Hemochromatosis caused by excessive vitamin iron intake. Am J Pathol 96: 611-624, 1979.

52. Hoogstraten J, de Sa DJ, Knisely AS: Fetal liver disease may precede extrahepatic siderosis in neonatal hemochromatosis. Gastroenterology 98: 1699-1701, 1990.

53. Hultcrantz R, Glaumann H, Lindberg G, Nilsson LH: Liver investigation in 149 asymptomatic patients with moderately elevated activities of serum aminotransferases. Scand J Gastroenterol 21: 109-113, 1986.

54. Irving MG, Halliday JW, Powell LW: Association between alcoholism and increased hepatic iron stores. Alcohol Clin Exp Res 12: 7-13, 1988.

55. Jakobovits AW, Morgan MY, Sherlock S: Hepatic siderosis in alcoholics. Dig Dis Sci 24: 305-310, 1979.

56. Jean G, Terzoli S, Mauri R, et al: Cirrhosis associated with multiple transfusions in thalassaemia. Arch Dis Child 59: 67-70, 1984.

57. Kent G, Popper H: Liver biopsy in diagnosis of hemochromatosis. Amer J Med 44: 837-841, 1968.

58. Kier R: Quantification of hepatic iron with CT and MRI: Practical considerations. Hepatology 12: 1441-1442, 1991.

59. Knisely AS: Neonatal hemochromatosis. Adv Pediatr 39: 383-403, 1992.

60. Knisely AS, Magid MS, Dische MR, Cutz E: Neonatal hemochromatosis. Birth Defects 23: 75-102, 1987.

61. Knisely AS, O'Shea PA, Stocks JF, Dimmick JE: Oropharyngeal and upper respiratory tract mucosal-gland siderosis in neonatal hemochromatosis: An approach to biopsy diagnosis. J Pediatr 113: 871-874, 1988.

62. Kothari T, Swamy AP, Lee JCK, et al: Hepatic hemosiderosis in maintenance hemodialysis (MHD) patients. Dig Dis Sci 25: 363-368, 1980.

63. LeSage GD, Baldus WP, Fairbanks VF, et al: Hemochromatosis: Genetic or alcohol-induced? Gastroenterology 84: 1471-1477, 1983.

64. Ley TJ, Griffith P, Nienhuis AW: Tranfusion haemosiderosis and chelation therapy. Clin Haematol 11: 437-464, 1982.

65. Lombard CM, Strauchen JA: Postshunt hemochromatosis with cardiomyopathy. Hum Pathol 12: 1149-1151, 1981.

66. Lombard M, Bomford AB, Polson RJ, et al: Differential expression of transferrin receptor in duodenal mucosa in iron overload. Evidence for a site-specific defect in genetic hemochromatosis. Gastroenterology 98: 976-984, 1990.

67. McLaren GD: Reticuloendothelial iron stores and hemochromatosis: A paradox. J Lab Clin Med 113: 137-140, 1989.

68. McLaren GD, Nathanson MH, Jacobs A, et al: Regulation of intestinal iron absorption and mucosal iron kinetics in hereditary hemochromatosis. J Lab Clin Med 117: 390-401, 1991.

69. Moerman P, Pauwels P, Vandenberghe K, et al: Neonatal haemochromatosis. Histopathology 17: 345-351, 1990.

70. Nichols GM, Bacon BR: Hereditary hemochromatosis: Pathogenesis and clinical features of a common disease. Am J Gastroenterol 84: 851-862, 1989.

71. Niederau C, Fischer R, Sonnenberg A, et al: Survival and causes of death in cirrhotic and in noncirrhotic patients with primary hemochromatosis. N Engl J Med 313: 1256-1262, 1985.

72. Olynyk J, Hall P, Sallie R, et al: Computerized measurement of iron in liver biopsies: A comparison with biochemical iron measurement. Hepatology 12: 26-30, 1990.

73. Peto TEA, Pippard MJ, Weatherall DJ: Iron overload in mild sideroblastic anaemias. Lancet 1: 375-378, 1983.

74. Pootrakul P, Kitcharoen K, Yansukon P, et al: The effect of erythroid hyperplasia on iron balance. Blood 71: 1124-1129, 1988.

75. Powell LW, Bassett ML, Halliday JW: Hemochromatosis: 1980 update. Gastroenterology 78: 374-381, 1980.

76. Powell LW, Kerr JFR: The pathology of the liver in hemochromatosis. Pathobiol Annu 5: 317-337, 1975.

77. Powell LW, Summers KM, Board PG, et al: Expression of hemochromatosis in homozygous subjects. Implications for early diagnosis and prevention. Gastroenterology 98: 1625-1632, 1990.

78. Rao KV, Anderson WR: Hemosiderosis and hemochromatosis in renal transplant recipients. Clinical and pathological features, diagnostic correlations, predisposing factors, and treatment. Am J Nephrol 5: 419-430, 1985.

79. Richter GW: The iron-loaded cell -- The cytopathology of iron storage. Am J Pathol 91: 363-396, 1978.

80. Risdon RA, Barry M, Flynn DM: Transfusional iron overload: The relationship between tissue iron concentration and hepatic fibrosis in thalassaemia. J Pathol 116: 83-95, 1975.

81. Rowe JW, Wands JR, Mezey E, et al: Familial hemochromatosis: Characteristics of the pre-cirrhotic stage in a large kindred. Medicine 56: 197-211, 1977.

82. Sallie RW, Reed WD, Shilkin KB: Confirmation of the efficacy of hepatic tissue iron index in differentiating genetic haemochromatosis from alcoholic liver disease complicated by alcoholic haemosiderosis. Gut 32: 207-210, 1991.

83. Schafer AI, Cheron RG, Dluhy R, et al: Clinical consequences of acquired tranfusional iron overload in adults. N Engl J Med 304: 319-324, 1981.

84. Scheuer PJ, Williams R, Muir AR: Hepatic pathology in relatives of patients with hæmochromatosis. J Pathol Bacteriol 84: 53-64, 1962.

85. Silver MM, Beverley DW, Valberg LS, et al: Perinatal hemochromatosis. Clinical, morphologic, and quantitative iron studies. Am J Pathol 128: 538-554, 1987.

86. Simon M: Secondary iron overload and the haemochromatosis allelle. Br J Haematol 60: 1-5, 1985.

87. Simon M, Brissot P: The genetics of haemochromatosis. J Hepatol 6: 116-124, 1988.

88. Sindram JW, Marx JJM: Localization of iron in the hepatic acini and bile duct epithelium as a tool for estimation of liver iron overload. Ann NY Acad Sci 526: 361-362, 1988.

89. Stevens RG, Jones DY, Micozzi MS, Taylor PR: Body iron stores and the risk of cancer. N Engl J Med 319: 1047-1052, 1988.

90. Summers KM, Halliday JW, Powell LW: Identification of homozygous hemochromatosis subjects by measurement of hepatic iron index. Hepatology 12: 20-25, 1990.

91. Tavill AS, Bacon BR: Hemochromatosis: How much iron is too much? Hepatology 6: 142-145, 1986.

92. Tavill AS, Sharma BK, Bacon BR: Iron and the liver: Genetic hemochromatosis and other hepatic iron overload disorders. Prog Liver Dis 9: 281-305, 1990.

93. Tiniakos G, Williams G: Cirrhotic process, liver cell carcinoma and extrahepatic malignant tumors in idiopathic haemochromatosis. Study of 71 patients treated with venesection therapy. Appl Pathol 6: 128-138, 1988.

94. Van Ness MM, Diehl AM: Is liver biopsy useful in the evaluation of patients with chronically elevated liver enzymes? Ann Intern Med 111: 473-478, 1989.

95. Walker RJ, Miller JPG, Dymock IW, et al: Relationship of hepatic iron concentration to histochemical grading and to total chelatable body iron in conditions associated with iron overload. Gut 12: 1011-1014, 1971.

96. Weintraub LR, Goral A, Grasso J, et al: Pathogenesis of hepatic fibrosis in experimental iron overload. Br J Haematol 59: 321-331, 1985.

97. Weir MP, Sharp GA, Peters TJ: Electron microscopic studies of human haemosiderin and ferritin. J Clin Pathol 38: 915-918, 1985.

98. Witzleben CL, Uri A: Perinatal hemochromatosis: Entity or end result? Hum Pathol 20: 335-340, 1989.

COPPER ACCUMULATION

99. Berman DH, Leventhal RI, Gavaler JS, et al: Clinical differentiation of fulminant Wilsonian hepatitis from other causes of hepatic failure. Gastroenterology 100: 1129-1134, 1991.

100. Bhusnurmath SR, Walia BNS, Singh S, et al: Sequential histopathologic alterations in Indian childhood cirrhosis treated with d-penicillamine. Hum Pathol 22: 653-658, 1991.

101. Brewer GJ, Yuzbasiyan-Gurkan V: Wilson disease. Medicine 71: 139-164, 1992.

102. Cheng WS, Govindarajan S, Redeker AG: Hepatocellular carcinoma in a case of Wilson's disease. Liver 12: 42-45, 1992.

103. Czaja MJ, Weiner FR, Schwarzenberg SJ, et al: Molecular studies of ceruloplasmin deficiency in Wilson's disease. J Clin Invest 80: 1200-1204, 1987.

103a. Davies SE, Williams R, Portmann B: Hepatic morphology and histochemistry of Wilson's disease presenting as fulminant hepatic failure: a study of 11 cases. Histopathology 15: 385-394, 1989.

104. Deiss A, Lynch RE, Lee GR, Cartwright GE: Long-term therapy of Wilson's disease. Ann Intern Med 75: 57-65, 1971.

105. Dobyns WB, Goldstein NP, Gordon H: Clinical spectrum of Wilson's disease (hepatolenticular degeneration). Mayo Clin Proc 54: 35-42, 1979.

106. Elmes ME, Clarkson JP, Mahy NJ, Jasani B: Metallothionein and copper in liver disease with copper retention -- a histopathologic study. J Pathol 158: 131-137, 1989.

107. Epstein O, Sherlock S: Is Wilson's disease caused by a controller gene mutation resulting in perpetuation of the fetal mode of copper metabolism into childhood? Lancet 1: 303-305, 1981.

108. Faa G, Liguori C, Columbano A, Diaz G: Uneven copper distribution in the human newborn liver. Hepatology 7: 838-842, 1987.

109. Finegold MJ: Successful treatment of Indian childhood cirrhosis. Hum Pathol 22: 633, 1991.

110. Fuller CE, Elmes ME, Jasani B: Age-related changes in metallothionein, copper, copper-associated protein, and lipofuscin in human liver: A histochemical and immunohistochemical study. J Pathol 161: 167-172, 1990.

111. Geubel AP, Gregoire V, Rahier J, et al: Hypoceruloplasminemia and ultrastructural changes resembling Wilson's disease in nonalcoholic liver steatosis. A clinical and pathological study of five cases. Liver 8: 299-306, 1988.

112. Goldfischer S, Popper H, Sternlieb I: The significance of variations in the distribution of copper in liver disease. Am J Pathol 99: 715-730, 1980.

113. Guarascio P, Yentis F, Cervikbas U, et al: Value of copper-associated protein in diagnostic assessment of liver biopsy. J Clin Pathol 36: 18-23, 1983.

114. Haratake J, Horie A, Takeda S: Histochemical and ultrastructural study of copper-binding protein in hepatocellular carcinoma. Cancer 60: 1269-1274, 1987.

115. Irons RD, Schenk EA, Lee JCK: Cytochemical methods for copper. Semiquantitative screening procedure for identification of abnormal copper levels in liver. Arch Pathol Lab Med 101: 298-301, 1977.

116. Iyengar V, Brewer GJ, Dick RD, Owyang C: Studies of cholecystokinin-stimulated biliary secretions reveal a high molecular weight copper-binding substance in normal subjects that is absent in patients with Wilson's disease. J Lab Clin Med 111: 267-274, 1988.

117. Jain S, Scheuer PJ, Archer B, et al: Histological demonstration of copper and copper-associated protein in chronic liver diseases. J Clin Pathol 31: 784-790, 1978.

118. Joshi VV: Indian childhood cirrhosis. Perspect Pediatr Pathol 11: 175-192, 1987.

119. Klass HJ, Kelly JK, Warnes TW: Indian childhood cirrhosis in the United Kingdom. Gut 21: 344-350, 1980.

120. Lefkowitch JH, Honig CL, King ME, Hagstrom JWC: Hepatic copper overload and features of Indian childhood cirrhosis in an American sibship. N Engl J Med 307: 271-277, 1982.

121. Lindquist RR: Studies on the pathogenesis of hepatolenticular degeneration. II. Cytochemical methods for the localization of copper. Arch Pathol 87: 370-378, 1969.

122. Marsden CD: Wilson's disease. Q J Med 65: 959-966, 1987.

123. McCullough AJ, Fleming CR, Thistle JL, et al: Diagnosis of Wilson's disease presenting as fulminant hepatic failure. Gastroenterology 84: 161-167, 1983.

124. Mehrotra R, Pandey RK, Nath P: Hepatic copper in Indian childhood cirrhosis. Histopathology 5: 659-665, 1981.

125. Müller-Höcker J, Meyer U, Wiebecke B, et al: Copper storage disease of the liver and chronic dietary copper intoxication in two further German infants mimicking Indian childhood cirrhosis. Pathol Res Pract 183: 39-45, 1988.

126. Müller-Höcker J, Weiß M, Meyer U, et al: Fatal copper storage disease of the liver in a German infant resembling Indian childhood cirrhosis. Virchows Arch [A] 411: 379-385, 1987.

127. Nartey NO, Frei JV, Cherian MG: Hepatic copper and metallothionein distribution in Wilson's disease (hepatolenticular degeneration). Lab Invest 57: 397-401, 1987.

128. Nazer H, Ede RJ, Mowat AP, Williams R: Wilson's disease: clinical presentation and use of prognostic index. Gut 27: 1377-1381, 1986.

129. O'Neill NC, Tanner MS: Uptake of copper from brass vessels by bovine milk and its relevance to Indian childhood cirrhosis. J Pediatr Gastroenterol Nutr 9: 167-172, 1989.

130. Pimentel JC, Menezes AP: Liver disease in vineyard sprayers. Gastroenterology 72: 275-283, 1977.

131. Polio J, Enriquez RE, Chow A, et al: Hepatocellular carcinoma in Wilson's disease. Case report and review of literature. J Clin Gastroenterol 11: 220-224, 1989.

132. Polson RJ, Rolles K, Calne RY, et al: Reversal of severe neurological manifestations of Wilson's disease following orthotopic liver transplantation. Q J Med 244: 685-691, 1987.

133. Rakela J, Kurtz SB, McCarthy JT, et al: Fulminant Wilson's disease treated by postdilution hemofiltration and orthotopic liver transplantation. Gastroenterology 90: 2004-2007, 1986.

134. Saito T: Presenting symptoms and natural history of Wilson disease. Eur J Pediatr 146: 261-265, 1987.

135. Scheinberg IH, Sternlieb I: Wilson's Disease. Philadelphia, 1984, W.B. Saunders.

136. Schilsky ML, Scheinberg IH, Sternlieb I: Prognosis of Wilsonian chronic active hepatitis. Gastroenterology 100: 762-767, 1991.

137. Scott J, Gollan JL, Samourian S, Sherlock S: Wilson's disease, presenting as chronic active hepatitis. Gastroenterology 74: 645-651, 1978.

138. Shikata T: Morphogenesis of liver cirrhosis in Wilson's disease. Birth Defects 4: 88-91, 1968.

139. Spechler SJ, Koff RS: Wilson's disease: Diagnostic difficulties in the patient with chronic hepatitis and hypoceruloplasminemia. Gastroenterology 78: 803-806, 1980.

140. Sternlieb I: Copper and zinc. In Arias IM, Jakoby WB, Popper H, et al (eds): The Liver: Biology and Pathobiology, 2nd ed. New York, 1988, Raven Press. pp 525-533.

141. Sternlieb I: Perspectives on Wilson's disease. Hepatology 12: 1234-1239, 1990.

142. Stremmel W, Meyerrose K-W, Niederau C, et al: Wilson disease: Clinical presentation, treatment, and survival. Ann Intern Med 115: 720-726, 1991.

143. Stromeyer FW, Ishak KG: Histology of the liver in Wilson's disease. A study of 34 cases. Am J Clin Pathol 73: 12-24, 1980.

144. Sumithran E, Looi LM: Copper-binding protein in liver cells. Hum Pathol 16: 677-682, 1985.

145. Tanner MS, Portmann B: Indian childhood cirrhosis. Arch Dis Child 56: 4-6, 1981.

146. Walshe JM: Diagnosis and treatment of presymptomatic Wilson's disease. Lancet 2: 435-437, 1988.

147. Walshe JM: Wilson's disease presenting with featurs of hepatic dysfunction: A clinical analysis of eighty-seven patients. Q J Med 70: 253-263, 1989.

148. Yuzbasiyan-Gurkan V, Johnson V, Brewer GJ: Diagnosis and characterization of presymptomatic patients with Wilson's disease and the use of molecular genetics to aid in the diagnosis. J Lab Clin Med 118: 458-465, 1991.

CYTOPLASMIC INCLUSIONS

149. Alagille D: α1-antitrypsin deficiency. Hepatology 4: 11S-14S, 1984.

150. Bell H, Schrumpf E, Fagerhol MK: Heterozygous alpha-1-antitrypsin deficiency in adults with chronic liver disease. Scand J Gastroenterol 25: 788-792, 1990.

151. Birrer P, McElvaney NG, Chang-Stroman LM, Crystal RG: α1-antitrypsin deficiency and liver disease. J Inher Metab Dis 14: 512-525, 1991.

152. Brantly M, Nukiwa T, Crystal RG: Molecular basis of alpha-1-antitrypsin deficiency. Am J Med 84 (suppl 6A): 13-31, 1988.

153. Brind AM, Bassendine MF, Bennett MK, James OFW: Alpha1-antitrypsin granules in the liver -- always important? Q J Med 76: 699-709, 1990.

154. Bruguera M, Lamar C, Bernet M, Rodés J: Hepatic disease associated with ground-glass inclusions in hepatocytes after cyanamide therapy. Arch Pathol lab Med 110: 906-910, 1986.

155. Callea F, DeVos R, Togni R, et al: Fibrinogen inclusions in liver cells: a new type of ground-glass hepatocyte. Immune light and electron microscopic characterization. Histopathology 10: 65-73, 1986.

156. Callea F, Fevery J, De Groote J, Desmet VJ: Detection of Pi Z phenotype individuals by alpha-1-antitrypsin (AAT) immunohistochemistry in paraffin-embedded liver tissue specimens. J Hepatol 2: 389-401, 1986.

157. Callea F, Fevery J, Massi G, et al: Storage of alpha-1-antitrypsin in intrahepatic bile duct cells in alpha-1-antitrypsin deficiency (PI Z phenotype). Histopathology 9: 99-108, 1985.

158. Carrell RW: α1-antitrypsin: Molecular pathology, leukocytes, and tissue damage. J Clin Invest 78: 1427-1431, 1986.

159. Carlson J: Endoplasmic reticulum storage disease. Histopathology 16: 309-312, 1990.

160. Carlson J, Eriksson S: Chronic 'cryptogenic' liver disease and malignant hepatoma in intermediate alpha1-antitrypsin deficiency identified by a Pi Z-specific monoclonal antibody. Scand J Gastroenterol 20: 835-842, 1985.

161. Carlson J, Eriksson S, Hågerstrand I: Intra- and extracellular alpha1-antitrypsin in liver disease with special reference to Pi phenotype. J Clin Pathol 34: 1020-1025, 1981.

162. Clausen PP, Lindskov J, Gad I, et al: The diagnostic value of α1-antitrypsin globules in liver cells as a morphologic marker of α1-antitrypsin deficiency. Liver 4: 353-359, 1984.

163. Cox DW: α1-antitrypsin deficiency. In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds): The Metabolic Basis of Inherited Disease, 6th ed. New York, 1989, McGraw Hill Information Services. pp 2409-2437.

164. Cox DW, Smyth S: Risk for liver disease in adults with alpha1-antitrypsin deficiency. Am J Med 74: 221-227, 1983.

165. Crowley JJ, Sharp HL, Freier E, et al: Fatal liver disease associated with α1-antitrypsin deficiency PiM1/PiMduarte. Gastroenterology 93: 242-244, 1987.

166. Cutz E, Cox DW: α1-antitrypsin deficiency: The spectrum of pathology and pathophysiology. Perspect Pediatr Pathol 5: 1-39, 1979.

167. Eriksson S: α1-antitrypsin deficiency and liver cirrhosis in adults. An analysis of 35 Swedish autopsied cases. Acta Med Scand 221: 461-467, 1987.

168. Eriksson S, Carlson J, Velez R: Risk of cirrhosis and primary liver cancer in alpha1-antitrypsin deficiency. N Engl J Med 314: 736-739, 1986.

169. Fagerhol MK, Cox DW: The Pi polymorphism. Genetic, biochemical, and clinical aspects of human α1-antitrypsin. Adv Hum Genet 11: 1-62, 1981.

170. Geller SA, Nichols WS, Dycaico MJ, et al: Histopathology of α1-antitrypsin liver disease in a transgenic mouse model. Hepatology 12: 40-47, 1990.

171. Gerber MA, Thung SN, Shen S, et al: Phenotypic characterization of hepatic proliferation: antigenic expression by proliferating epithelial cells in fetal liver, massive hepatic necrosis and nodular transformation of the liver. Am J Pathol 110: 70-74, 1983.

172. Ghishan FK, Greene HL: Liver disease in children with PiZZ α1-antitrypsin deficiency. Hepatology 8: 307-310, 1988.

173. Gordon HW, Dixon J, Rogers JC, et al: Alpha1-antitrypsin accumulation in livers of emphysematous patients with A1AT deficiency. Hum Pathol 3: 361-370, 1972.

174. Hadchouel M, Gautier M: Histopathologic study of the liver in the early cholestatic phase of alpha-1-antitrypsin deficiency. J Pediatr 89: 211-215, 1976.

175. Hall P, Herrmann R, Brennan J, Mackinnon M: Detection of alpha-1-antitrypsin in hepatocytes in acute and chronic hepatitis. Pathology 19: 415-418, 1987.

176. Hodges JR, Millward-Sadler GH, Barbatis C, Wright R: Heterozygous MZ alpha-1-antitrypsin deficiency in adults with chronic active hepatitis and cryptogenic cirrhosis. N Engl J Med 304: 557-560, 1981.

177. Hood JM, Koep LJ, Peters RL, et al: Liver transplantation for advanced liver disease with alpha-1-antitrypsin deficiency. N Engl J Med 302: 272-275, 1980.

178. Hussain M, Mieli-Vergani G, Mowat AP: α1-antitrypsin deficiency and liver disease: Clinical presentation, diagnosis, and treatment. J Inher Metab Dis 14: 497-511, 1991.

179. Hutchison DCS: Natural history of alpha-1-protease inhibitor deficiency. Am J Med 84 (suppl 6A): 3-12, 1988.

180. Kage M, Kage M, Liew CT, et al: Alpha-1-antitrypsin deficiency in adults. Acta Pathol Jpn 36: 1139-1148, 1986.

181. Klatt EC, Koss MN, Young TS, et al: Hepatic hyaline globules associated with passive congestion. Arch Pathol Lab Med 112: 510-513, 1988.

182. Larsson C: Natural history and life expectancy in severe alpha1-antitrypsin deficiency, PiZ. Acta Med Scand 204: 345-351, 1978.

183. Latimer JS, Sharp HL: Alpha-1-antitrypsin deficiency in childhood. Curr Probl Pediatr 11: 1-36, 1980.

184. Lindmark B, Sadler-Millward H, Callea F, Eriksson S: Hepatocyte inclusions of α1-antichymotrypsin in a patient with partial deficiency of α1-antichymotrypsin and chronic liver disease. Histopathology 16: 221-225, 1990.

185. Nakanuma Y, Ohta G, Matsubara F, et al: Cytoplasmic blood plasma inclusions in human hepatocytes. Liver 2: 212-221, 1982.

186. Nebbia G, Hadchouel M, Odievre M, Alagille D: Early assessment of evolution of liver disease associated with α1-antitrypsin deficiency in childhood. J Pediatr 102: 661-665, 1983.

187. Nemeth A, Strandvik B: Natural history of children with alpha1-antitrypsin deficiency and neonatal cholestasis. Acta Pædiatr Scand 71: 993-999, 1982.

188. Ng IOL, Ng M, Lai ECS, Wu PC: Endoplasmic storage disease of liver: characterization of intracytoplasmic hyaline inclusions. Histopathology 15: 473-481, 1989.

189. Ng IOL, Sturgess RP, Williams R, Portmann B: Ground-glass hepatocytes with Lafora body like inclusions -- histochemical, immunohistochemical and electronmicroscopic characterization. Histopathology 17: 109-115, 1990.

190. Nishimura RN, Ishak KG, Reddick R, et al: Lafora disease: diagnosis by liver biopsy. Ann Neurol 8: 409-415, 1980.

191. Odièvre M, Martin J-P, Hadchouel M, et al: Alpha1-antitrypsin deficiency and liver disease in children: Phenotypes, manifestations, and prognosis. Pediatrics 57: 226-231, 1976.

192. Palmer PE, Wolfe HJ: α1-antitrypsin deposition in primary hepatic carcinomas. Arch Pathol Lab Med 100: 232-236, 1976.

193. Palmer PE, Wolfe HJ, Dayal Y, Gang DL: Immunocytochemical diagnosis of alpha-1-antitrypsin deficiency. Am J Surg Pathol 2: 275-281, 1978.

194. Pariente E-A, Degott C, Martin J-P, et al: Hepatocytic PAS-positive diastase-resistant inclusions in the absence of alpha-1-antitrypsin deficiency -- High prevalence in alcoholic cirrhosis. Am J Clin Pathol 76: 299-302, 1981.

195. Perlmutter DH: The cellular basis for liver injury in α1-antitrypsin deficiency. Hepatology 13: 172-185, 1991.

196. Pittschieler K: Liver disease and heterozygous alpha-1-antitrypsin deficiency. Acta Pædiatr Scand 80: 323-327, 1991.

197. Propst T, Propst A, Dietze O, et al: High prevalence of viral infection in adults with homozygous and heterozygous alpha1-antitrypsin deficiency and chronic liver disease. Ann Intern Med 117: 641-645, 1992.

198. Psacharopoulos HT, Mowat AP, Cook PJL, et al: Outcome of liver disease associated with α1 antitrypsin deficiency (PiZ). Arch Dis Child 58: 882-887, 1983.

199. Qizilbash A, Young-Pong O: Alpha1 antrypsin liver disease differential diagnosis of PAS-positive, diastase-resistant globules in liver cells. Am J Clin Pathol 79: 697-702, 1983.

200. Rakela J, Goldschmiedt M, Ludwig J: Late manifestation of chronic liver disease in adults with alpha-1-antitrypsin deficiency. Dig Dis Sci 32: 1358-1362, 1987.

201. Reid CL, Wiener GJ, Cox DW, et al: Diffuse hepatocellular dysplasia and carcinoma associated with the Mmalton variant of α1-antitrypsin. Gastroenterology 93: 181-187, 1987.

202. Reintoft I: Periodic acid Schiff-positive non-glycogenic globules in hepatocytes. Differential diagnostic aspects in screening for alpha-1-antitrypsin globules in an autopsy material. Acta Pathol Microbiol Scand [A] 86: 325-329, 1978.

203. Reintoft I, Hågerstrand I: Demonstration of α1-antitrypsin in hepatomas. Arch Pathol Lab Med 103: 495-498, 1979.

204. Roberts EA, Cox DW, Medline A, Wanless IR: Occurrence of alpha-1-antitrypsin deficiency in 155 patients with alcoholic liver disease. Am J Clin Pathol 82: 424-427, 1984.

205. Roberts PF: PiZZ alpha1-antitrypsin in a 20-week fetus. Hum Pathol 16: 188-190, 1985.

206. Rubel LR, Ishak KG, Benjamin SB, Knuff TE: α1-antitrypsin deficiency and hepatocellular carcinoma. Association with cirrhosis, copper storage, and Mallory bodies. Arch Pathol Lab Med 106: 678-681, 1982.

207. Schwarzenberg SJ, Sharp HL: Pathogenesis of α1-antitrypsin deficiency-associated liver disease, 1990. J Pediatr Gastroenterol Nutr 10: 5-12, 1990.

208. Sveger T: The natural history of liver disease in α1-antitrypsin deficient children. Acta Pædiatr Scand 77: 847-851, 1988.

209. Talbot IC, Mowat AP: Liver disease in infancy: histological features and relationship to α1-antitrypsin phenotype. J Clin Pathol 28: 559-563, 1975.

210. Thatcher BS, Winkelman EI, Tuthill RJ: Alpha-1-antitrypsin deficiency presenting as cryptogenic cirrhosis in adults over 50. J Clin Gastroenterol 7: 405-408, 1985.

211. Theaker JM, Fleming KA: Alpha-1-antitrypsin and the liver: a routine immunohistological screen. J Clin Pathol 39: 58-62, 1986.

212. Vazquez JJ, Pardo-Mindan J: Liver cell injury (bodies similar to Lafora's) in alcoholics treated with disulfiram (Antabuse). Histopathology 3: 377-384, 1979.

213. Zubair I, Herrera GA, Pretlow TG II, et al: Cytoplasmic inclusions in hepatocytes of bone marrow transplant patients: Light and electron microscopic characterization. Am J Clin Pathol 83: 65-68, 1985.

CYTOPLASMIC RAREFACTION

214. Antonarakis SE, Valle D, Moser HW, et al: Phenotypic variability in siblings with Farber's disease. J Pediatr 104: 406-409, 1984.

215. Aylsworth AS, Thomas GH, Hood JL, et al: A severe infantile sialidosis: Clinical, biochemical and microscopic features. J Pediatr 96: 662-668, 1980.

216. Bannayan GA, Dean WJ, Howell RR: Type IV glycogen-storage disease. Light-microscopic, electron-microscopic, and enzymatic study. Am J Clin Pathol 66: 702-709, 1976.

217. Beutler E: Gaucher's disease. N Engl J Med 325: 1354-1360, 1991.

218. Brady RO, James SP, Barranger JA: The liver in lipid storage disease: Biochemical basis of pathogenesis and clinical features. Prog Liver Dis 7: 331-346, 1982.

219. Buchino JJ, Brown BI, Volk DM: Glycogen storage disease type Ib. Arch Pathol Lab Med 107: 283-285, 1983.

220. Burgess JH, Kalfayan B, Stungaard RK, Gilbert E: Papillomatosis of the gallbladder associated with metachromatic leukodystrophy. Arch Pathol Lab Med 109: 79-81, 1985.

221. Coire CI, Qizilbash AH, Castelli MF: Hepatic adenomata in type Ia glycogen storage disease. Arch Pathol Lab Med 111: 166-169, 1987.

222. D'Agostino D, Bay L, Gallo G, Chamoles N: Cholesterol ester storage disease: clinical, biochemical, and pathological studies of four new cases. J Pediatr Gastroenterol Nutr 7: 446-450, 1988.

223. DiBisceglie AM, Ishak KG, Rabin L, Hoeg JM: Cholesteryl ester storage disease: Hepatopathology and effects of therapy with lovastatin. Hepatology 11: 764-772, 1990.

224. Dienes HP, Gerharz C-D, Wagner R, et al: Accumulation of hydroxyethyl starch (HES) in the liver of patients with renal failure and portal hypertension. J Hepatol 3: 223-227, 1986.

225. Dincsoy HP, Rolfes DB, McGraw CA, Schubert WK: Cholesterol ester storage disease and mesenteric lipodystrophy. Am J Clin Pathol 81: 263-269, 1984.

226. Fellows IW, Lowe JS, Ogilvie AL, et al: Type III glycogenosis presenting as liver disease in adults with atypical histological features. J Clin Pathol 36: 431-434, 1983.

227. Glew RH, Basu A, Prence EM, Remaley AT: Lysosomal storage diseases. Lab Invest 53: 250-269, 1985.

228. Greene HL: Glycogen storage disease. Semin Liver Dis 2: 291-301, 1982.

229. Guigui B, Perrot S, Berry JP, et al: Amiodarone-induced hepatic phosphoslipidosis: A morphologic alteration independent of pseudoalcoholic liver disease. Hepatology 8: 1063-1068, 1988.

230. Hers H-G, Van Hoof F, de Barsy T: Glycogen storage diseases. In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds): The Metabolic Basis of Inherited Disease, 6th ed. New York, 1989, McGraw Hill Information Services. pp 425-452.

231. Itoh S, Ishida Y, Matsuo S: Mallory bodies in a patient with type Ia glycogen storage disease. Gastroenterology 92: 520-523, 1987.

232. James SP, Stromeyer FW, Chang C: Liver abnormalities in patients with Gaucher's disease. Gastroenterology 80: 126-133, 1981.

233. Lake BD: The role of histochemical investigations in metabolic disorders affecting the liver. J Inher Metab Dis 14: 538-545, 1991.

234. Lewis JH, Mullick F, Ishak KG, et al: Histopathologic analysis of suspected amiodarone hepatotoxicity. Hum Pathol 21: 59-67, 1990.

235. McAdams AJ, Hug G, Bove KE: Glycogen storage disease, types I to X. Criteria for morphologic diagnosis. Hum Pathol 5: 463-487, 1974.

236. Meuwissen SGN, Dingemans KP, Stryland A, et al: Ultrastructural and biochemical liver analyses in Fabry's disease. Hepatology 2: 263-268, 1982.

237. Miller R, Bialer MG, Rogers JF, et al: Wolman's disease. Report of a case, with multiple studies. Arch Pathol Lab Med 106: 41-45, 1982.

238. Muñoz SJ, Martinez-Hernandez A, Maddrey WC: Intrahepatic cholestasis and phospholipidosis associated with the use of trimethoprim-sulfamethoxazole. Hepatology 12: 342-347, 1990.

239. Neufeld EF, Muenzer J: The mucopolysaccharidoses. In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds): The Metabolic Basis of Inherited Disease, 6th ed. New York, 1989, McGraw Hill Information Services. pp 1565-1587.

240. Nolan CM, Sly WS: I-cell disease and pseudo-Hurler polydystrophy: Disorders of lysosomal enzyme phosphorylation and localization. In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds): The Metabolic Basis of Inherited Disease, 6th ed. New York, 1989, McGraw Hill Information Services. pp 1589-1601.

241. Parfrey NA, Hutchins GM: Hepatic fibrosis in the mucopolysaccharidoses. Am J Med 81: 825-829, 1986.

242. Parker P, Burr I, Slonim A, et al: Regression of hepatic adenomas in type Ia glycogen storage disease with dietary therapy. Gastroenterology 81: 534-536, 1981.

243. Petrelli M, Blair JD: The liver in GM1 gangliosidosis types 1 and 2. A light and electron microscopical study. Arch Pathol 99: 111-116, 1975.

244. Poe R, Snover DC: Adenomas in glycogen storage disease type I. Two cases with unusual histologic features. Am J Surg Pathol 12: 477-483, 1988.

245. Riches WG, Smuckler EA: A severe infantile mucolipidosis: Clinical, biochemical and pathologic features. Arch Pathol Lab Med 107: 147-150, 1983.

246. Selby R, Starzl TE, Yunis E, et al: Liver transplantation for type IV glycogen storage disease. N Engl J Med 324: 39-42, 1991.

247. Semeraro LA, Riely CA, Kolodny EH, et al: Niemann-Pick variant lipidosis presenting as "neonatal hepatitis." J Pediatr Gastroenterol Nutr 5: 492-500, 1986.

248. Smanik EJ, Tavill AS, Jacobs GH, et al: Orthotopic liver transplantation in two adults with Niemann-Pick and Gaucher's disease: Implications for the treatment of inherited metabolic disease. Hepatology 17: 42-49, 1993.

249. Spence MW, Callahan JW: Sphinogmyelin-cholesterol lipidoses: The Niemann-Pick group of diseases. In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds): The Metabolic Basis of Inherited Disease, 6th ed. New York, 1989, McGraw Hill Information Services. pp 1655-1676.

250. Stone R, Benson J, Tronic B, et al: Hepatic calcifications in a patient with Gaucher's disease. Am J Gastroenterol 77: 95-98, 1982.

FATTY CHANGE AND CHOLESTASIS

251. Applebaum MN, Thaler MM: Reversibility of extensive liver damage in galactosemia. Gastroenterol 69: 496-502, 1975.

252. Burmeister LA, Valdivia T, Nuttall FQ: Adult hereditary fructose intolerance. Arch Intern Med 151: 773-776, 1991.

253. Carson NAJ, Biggart JD, Bittles AH, Donovan D: Hereditary tyrosinaemia. Clinical, enzymatic, and pathological study of an infant with the acute form of the disease. Arch Dis Child 51: 106-113, 1976.

254. Cox TM: Hereditary fructose intolerance. Q J Med 68: 585-594, 1988.

255. Dehner LP, Snover DC, Sharp HL, et al: Hereditay tyrosinemia type I (chronic form): Pathologic findings in the liver. Hum Pathol 20: 149-158, 1989.

256. Gitzelmann R, Steinmann B, Van Den Berghe G: Disorders of fructose metabolism. In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds): The Metabolic Basis of Inherited Disease, 6th ed. New York, 1989, McGraw Hill Information Services. pp 399-424.

257. Goldsmith LA, Laberge C: Tyrosinemia and related disorders. In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds): The Metabolic Basis of Inherited Disease, 6th ed. New York, 1989, McGraw Hill Information Services. pp 547-562.

258. Hardwick DF, Dimmick JE: Metabolic cirrhoses of infancy and early childhood. Perspect Pediatr Pathol 3: 103-144, 1976.

259. Holton JB: Galactose disorders: an overview. J Inher Metab Dis 13: 476-486, 1990.

260. Kliegman RM, Sparks JW: Perinatal galactose metabolism. J Pediatr 107: 831-841, 1985.

261. Kvittingen EA: Hereditary tyrosinemia type I -- an overview. Scand J Clin Lab Invest 46 (suppl 184): 27-34, 1986.

262. Levin B, Snodgrass GJAI, Oberholzer VG, et al: Fructosaemia. Observations on seven cases. Am J Med 45: 826-838, 1968.

263. Manowski Z, Silver MM, Roberts EA, et al: Liver cell dysplasia and early liver transplantation in hereditary tyrosinemia. Mod Pathol 3: 694-701, 1990.

264. Medline A, Medline NM: Galactosemia: early structural changes in the liver. Can Med Assoc J 107: 877-878, 1972.

265. Mieles LA, Esquivel CO, Van Thiel DH, et al: Liver transplantation for tyrosinemia. A review of 10 cases from the University of Pittsburgh. Dig Dis Sci 35: 153-157, 1990.

266. Odièvre M, Gentil C, Gautier M, Alagille D: Hereditary fructose intolerance in children. Diagnosis, management, and course in 55 patients. Am J Dis Child 132: 605-608, 1978.

267. Otto G, Herfarth C, Senninger N, et al: Hepatic transplantation in galactosemia. Transplantation 47: 902-903, 1989.

268. Paradis K, Weber A, Seidman EG, et al: Liver transplantation for hereditary tyrosinemia: The Quebec experience. Am J Hum Genet 47: 338-342, 1990.

269. Russo P, O'Regan S: Visceral pathology of hereditary tyrosinemia type I. Am J Hum Genet 47: 317-324, 1990.

270. Segal S: Disorders of galactose metabolism. In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds): The Metabolic Basis of Inherited Disease, 6th ed. New York, 1989, McGraw Hill Information Services. pp 453-480.

271. Smetana HF, Olen E: Hereditary galactose disease. Am J Clin Pathol 38: 3-25, 1962.

272. Suzuki H, Gilbert EF, Anido V, et al: Galactosemia. A report of two fatal cases with giant cell transformation of the liver in one. Arch Pathol 82: 602-609, 1966.

273. Tazawa Y, Kikuchi M, Kurobane I, et al: An acute form of tyrosinemia type I with multiple intrahepatic mass lesions. J Pediatr Gastroenterol Nutr 10: 536-539, 1990.

274. Weinberg AG, Mize CE, Worthen HG: The occurrence of hepatoma in the chronic form of hereditary tyrosinemia. J Pediatr 88: 434-438, 1976.

MISCELLANEOUS DISORDERS

275. Allaire GS, Goodman ZD, Ishak KG, Rabin L: Talc in liver tissue of intravenous drug abusers with chronic hepatitis. Am J Clin Pathol 92: 583-588, 1989.

276. Beaumont C, Fauchet R, Phung LN, et al: Porphyria cutanea tarda and HLA-linked hemochromatosis: Evidence against a systematic association. Gastroenterology 92: 1833-1838, 1987.

277. Biempica L, Kosower N, Ma MH, Goldfischer S: Hepatic porphyria: cytochemical and ultrastructural studies of the liver in acute intermittent porphyria and porphyria cutanea tarda. Arch Pathol 98: 336-343, 1974.

278. Bloomer JR: The liver in protoporphyria. Hepatology 8: 402-407, 1988.

279. Bloomer JR, Weimer MK, Bossenmaier IC, et al: Liver transplantation in a patient with protoporphyria. Gastroenterology 97: 188-194, 1989.

280. Bonkowsky HL, Schned AR: Fatal liver disease in protoporphyria: Synergism between ethanol excess and the genetic defect. Gastroenterology 90: 191-201, 1986.

281. Buck FS, Koss MN: Hepatic amyloidosis: Morphologic differences between systemic AL and AA types. Hum Pathol 22: 904-907, 1991.

282. Campo E, Bruguera M, Rodes J: Are there diagnostic histologic features of porphyria cutanea tarda in liver biopsy specimens? Liver 10: 185-190, 1990.

283. Chopra S, Rubinow A, Koff RS, Cohen AS: Hepatic amyloidosis. A histopathologic analysis of primary (AL) and secondary (AA) forms. Am J Pathol 115: 186-193, 1984.

284. Cortés JM, Oliva H, Paradinas FJ, Hernandez-Guío C: The pathology of the liver in porphyria cutanea tarda. Histopathology 4: 471-485, 1980.

285. Cripps DJ, Scheuer PJ: Hepatobiliary changes in erythropoietic protoporphyria. Arch Pathol 80: 500-508, 1965.

286. Danks DM, Tippett P, Adams C, Campbell P: Cerebro-hepato-renal syndrome of Zellweger. A report of eight cases with comments upon the incidence, the liver lesion, and a fault in pipecolic acid metabolism. J Pediatr 86: 382-387, 1975.

287. Fakan F, Chlumská A: Demonstration of needle-shaped hepatic inclusions in porphyria cutenea tarda using the ferric ferricyanide reduction test. Virchows Arch [A] 411: 365-368, 1987.

288. Finkelstein SD, Fornasier VL, Pruzanski W: Intrahepatic cholestasis with predominant pericentral deposition in systemic amyloidosis. Hum Pathol 12: 470-472, 1981.

289. French SW, Schloss GT, Stillman AE: Unusual amyloid bodies in human liver. Am J Clin Pathol 75: 400-402, 1981.

290. Gaskin KJ, Waters DLM, Howman-Giles R, et al: Liver disease and common-bile-duct stenosis in cystic fibrosis. N Engl J Med 318: 340-346, 1988.

291. Gilbert EF: Carnitine deficiency. Pathology 17: 161-171, 1985.

292. Goldfischer S, Moore CL, Johnson AB, et al: Peroxisomal and mitochondrial defects in the cerebro-hepato-renal syndrome. Science 182: 62-64, 1972.

293. Guertin SR, Levinsohn MW, Dahms BB: Small-droplet steatosis and intracranial hypertension in argininosuccinic lysase deficiency. J Pediatr 102: 736-740, 1983.

294. Hughes JL, Poulos A, Robertson E, et al: Pathology of hepatic peroxisomes and mitochrondria in patients with peroxisomal disorders. Virchows Arch [A] 416: 255-264, 1990.

295. Hultcrantz R, Mengarelli S, Strandvik B: Morphological findings in the liver of children with cystic fibrosis: A light and electron microscopic study. Hepatology 6: 881-889, 1986.

296. Jaffe R, Crumrine P, Hashida Y, Moser HW: Neonatal adrenoleukodystrophy. Clinical, pathologic, and biochemical delineation of a syndrome affecting both males and females. Am J Pathol 108: 100-11, 1982.

297. Kanel GC, Uchida T, Peters RL: Globular hepatic amyloid -- an unusual morphologic presentation. Hepatology 1: 647-652, 1981.

298. Klatskin G, Bloomer JR: Birefringence of hepatic pigment deposits in erythropoietic protoporphyria. Gastroenterology 67: 294-302, 1974.

299. Kushner JP, Edwards CQ, Dadone MM, Skolnick MH: Heterozygosity for HLA-linked hemochromatosis as a likely cause of the hepatic siderosis associated with sporadic porphyria cutanea tarda. Gastroenterology 88: 1232-1238, 1985.

300. LeFevre ME, Green FHY, Joel DD, Laqueur W: Frequency of black pigment in livers and spleens of coal workers: Correlation with pulmonary pathology and occupational information. Hum Pathol 13: 1121-1126, 1982.

301. Lefkowitch JH, Grossman ME: Hepatic pathology in porphyria cutanea tarda. Liver 3: 19-29, 1983.

302. Looi LM, Sumithran E: Morphological differences in the pattern of liver infiltration between systemic AL and AA amyloidosis. Hum Pathol 19: 732-735, 1988.

303. Mooi WJ, Dingemans KP, van den Bergh Weerman MA, et al: Ultrastructure of the liver in the cerebrohepatorenal syndrome of Zellweger. Ultrastruct Pathol 5: 135-144, 1983.

304. Nagel RA, Javaid A, Meire HB, et al: Liver disease and bile duct abnormaltities in adults with cystic fibrosis. Lancet 2: 1422-1425, 1989.

305. Naritomi K, Hyakuna N, Suzuki Y, et al: Zellweger syndrome and a microdeletion of the proximal long arm of chromosome 7. Hum Genet 80: 201-202, 1988.

306. Oppenheimer EH, Esterly JR: Pathology of cystic fibrosis. Review of the literature and comparison with 146 autopsied cases. Perspect Pediatr Pathol 2: 241-278, 1975.

307. Psacharopoulos HT, Howard ER, Portmann B, et al: Hepatic complications of cystic fibrosis. Lancet 2: 78-80, 1981.

308. Rosenstein BJ, Oppenheimer EH: Prolonged obstructive jaundice and giant cell hepatitis in an infant with cystic fibrosis. J Pediatr 91: 1022-1023, 1977.

309. Roy CC, Weber AM, Morin CL, et al: Hepatobiliary disease in cystic fibrosis: A survey of current issues and concepts. J Pediatr Gastroenterol Nutr 1: 469-478, 1982.

310. Schutgens RBH, Heymans HSA, Wanders RJA, et al: Peroxisomal disorders: A newly recognized group of genetic diseases. Eur J Pediatr 144: 430-440, 1986.

311. Singh I, Johnson GH, Brown FR III: Peroxisomal disorders: biochemical and clinical diagnostic considerations. Am J Dis Child 142: 1297-1301, 1988.

312. Slavin RE, Swedo JL, Brandes D, et al; Extrapulmonary silicosis: A clinical, morphologic, and ultrastructural study. Hum Pathol 16: 393-412, 1985.

313. Strandvik B, Hjelte L, Gabrielsson N, Glaumann H: Sclerosing cholangitis in cystic fibrosis. Scand J Gastroenterol 23 (suppl 143): 121-124, 1988.

314. Totterman KJ, Manninen V: Tumefactive liver infiltration in amyloidosis. Ann Clin Res 14: 11-14, 1982.

315. Treem WR, Witzleben CA, Piccoli DA, et al: Medium-chain and long-chain acyl CoA dehydrogenase deficiency: Clinical, pathologic and ultrastructural differentiation from Reye's syndrome. Hepatology 6: 1270-1278, 1986.

316. Vamecq J, Draye J, van Hoof F, et al: Multiple perosisomal enzymatic deficiency disorders: A comparative biochemical and morphologic study of Zellweger cerebrohepatorenal syndrome and neonatal adrenoleukodystrophy. Am J Pathol 125: 524-535, 1986.

317. Waldo ED, Tobias H: Needle-like cytoplasmic inclusions in the liver in porphyria cutanea tarda. Arch Pathol 96: 368-371, 1973.

318. Wilson GN, Holmes RD, Hajra AK. Peroxisomal disorders: Clinical commentary and future prospects. Am J Med Genet 30: 771-792, 1988.