Figure 3. This is a low power magnification of a biopsy specimen, which was diagnosed as "Indeterminate" for acute rejection. Note that although a portal infiltrate is present, there is no significant bile duct damage nor venous endotheliitis. It should be emphasized however, that the diagnosis "Indeterminate" for acute rejection should be restricted only to those cases where the pathologist is reasonably confident that the infiltrate can be attributed to acute rejection. "Indeterminate" should not be used for specimens in which one is unsure whether or not rejection is present(e.g. chronic HCV).