Figure 3. Inclusion bodies typical of either herpes simplex or varicella-zoster virus infection may not always be detected in the biopsy. When present, they are most often located at the edge of the lesions in the rim of viable cells at the edge. However, if one suspects either of these infections the diagnosis should be immediately conveyed to the clinical physicians, even if the pathologist is not 100 percent certain of the diagnosis. Untreated, either of these infections involving the liver allograft can be rapidly fatal.