Figure 2. This plastic embedded section shows evidence of a little more severe cold preservation injury and the differential sensitivity of the endothelium lining the larger vessels as opposed to the sinusoids. Note the intact endothelium lining the central vein in this photomicrograph. In contrast, many of the sinusoidal endothelial cells are difficult to recognize, because they are detached from the underlying connective tissue and have assumed a "rounded" appearance. Note also the "blebs" on the surface of hepatocytes(arrows). These are small protrusions on the cytoplasmic membrane of damaged hepatocytes, and are a marker for hepatocellular injury.