Figure 9. A severe preservation-related insult, results within 2-3 days after transplantation in a ductular reaction in the periportal region. The cells appear to sprout from the near the canals of Herring and mostly show features of biliary epithelial differentiation. Sometimes this reaction produces histopathological changes that can be misinterpreted as biliary tract obstruction. However, the lack of periductal edema and neutrophils, involving the true bile duct in the middle of the portal connective tissue, argues against the diagnosis of biliary obstruction in this case.