Figure 7. Severe preservation injury can often be detected in biopsies obtained within only a few hours after transplantation. In this photomicrograph, note the periportal and perivenular congestion, hemorrhage, necrosis and neutrophilic inflammation. The combination of hepatocyte necrosis and severe neutrophilic inflammation in the areas of necrosis, signal a severe preservation-related injury, particularly if they are detected in the periportal region.