Figure 9. In some cases of chronic type B viral hepatitis, the portal inflammation is quite mild, yet there is a brisk ductular reaction and hepatocyte degenerative changes in the lobules(right side). The left side of the photomicrograph shows the abundant expression of HBcAg in the cytoplasm of degenerating hepatocytes. When these changes are marked, the pattern of injury has been called fibrosing cholestatic hepatitis.