Figure 1. A high power magnification of a large muscular artery from the hilum of the liver shows intimal foam cells accumulation that results in intimal(I) thickening. There are also foam cells in the media(M) and small foam cells and macrophages lined-up along the adventitia of the artery(A, arrow). Interestingly, some investigators have suggested that inflammatory cells originating from the adventitia of the artery can invade the media and intima, in an "outside-in" fashion.