Figure 6. Severe acute rejection can also be diagnosed in a needle biopsy. In this photomicrograph, note the presence of an inflammatory infiltrate expanding the portal tracts(PT). Note also the presence of inflammation in and around the central veins(CV). The inset shows the centrilobular region in greater detail. Lymphocytes are seen under the endothelium of the central vein, and extending out into the perivenular hepatic parenchyma. The associated hepatocyte necrosis and dropout are typical of a grade "3" venous damage in the Banff schema.