Figure 1. This example of severe acute rejection was taken from a failed allograft, removed several weeks after transplantation. Note the marked portal tract(PT) inflammation that focally spills over into the periportal hepatic parenchyma. A similar infiltrate is seen in and around the central veins(CV), and is associated with perivenular hepatocyte necrosis and dropout. The inset(upper left) shows an inflammatory and necrotizing arteritis with early focal foam cell deposition. This artery was present in a section taken from the hilum of the failed allograft. Arteritis is rarely detected in needle biopsies because the vessels most commonly affected are contained within the liver hilum and rarely sampled with a needle biopsy.