Contributed by Parmjeet S. Randhawa, M.D.
PATIENT HISTORY:
Per referral letter, the patient is an elderly female. S/P cadaver renal transplant. Creatinine 400. Review of outside material.

Final Diagnosis (Case 3)

PART 1: ALLOGRAFT KIDNEY, NEEDLE BIOPSY -
    INSUFFICIENT TISSUE IN THE BLOCK FOR DEFINITIVE INTERPRETATION; TUBULAR EPITHELIUM SHOWS EQUIVOCAL STAINING FOR SV40 ANTIGENS.

PART 2: ALLOGRAFT KIDNEY, NEEDLE BIOPSY -

    TUBULAR AND PARIETAL CAPSULAR EPITHELIUM SHOW STAINING FOR SV40 ANTIGENS.

PART 3: ALLOGRAFT KIDNEY, NEEDLE BIOPSY -

    TUBULAR EPITHELIUM SHOWS STAINING FOR SV40 ANTIGENS.

Comment:
The immunohistochemical findings are indicative of infection by the polyoma group of viruses. The antibody used does not distinguish between JC and BK viruses. However, the infection in this case is most likely due to BK virus, since the JC virus is believed to be pathogenic primarily in the central nervous system.

Previous Biopsies on this Patient:
None

TPIS Related Resources:
Kidney Transplant Topics


Gross Description - Case 3


The specimen consists of nine (9) consult slides with accompanying surgical pathology reports.


Microscopic Description - Case 3

Part 1

Part 2

Part 3


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