Contributed by Parmjeet S.
Randhawa, M.D.
PATIENT HISTORY:
Per referral letter, the patient is an elderly
female. S/P cadaver renal transplant. Creatinine 400.
Review of outside material.
Final Diagnosis (Case 3)
PART 1: ALLOGRAFT KIDNEY, NEEDLE BIOPSY
-
INSUFFICIENT TISSUE IN THE BLOCK FOR DEFINITIVE INTERPRETATION;
TUBULAR EPITHELIUM SHOWS EQUIVOCAL STAINING FOR SV40 ANTIGENS.
PART 2: ALLOGRAFT KIDNEY, NEEDLE BIOPSY -
TUBULAR AND PARIETAL CAPSULAR EPITHELIUM SHOW STAINING FOR SV40
ANTIGENS.
PART 3: ALLOGRAFT KIDNEY, NEEDLE BIOPSY -
TUBULAR EPITHELIUM SHOWS STAINING FOR SV40 ANTIGENS.
Comment:
The immunohistochemical findings are indicative of
infection by the polyoma group of viruses. The antibody used does not
distinguish between JC and BK viruses. However, the infection in this case is
most likely due to BK virus, since the JC virus is believed to be pathogenic
primarily in the central nervous system.
Previous Biopsies on this Patient:
None
TPIS Related Resources:
Kidney
Transplant Topics
Gross Description - Case 3
The specimen consists of nine (9) consult
slides with accompanying surgical pathology reports.
Microscopic Description - Case 3
Part 1
Part 2
Part 3
Please mail comments, corrections or suggestions to the TPIS administration at the
UPMC.
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