Severe Acute Rejection

Cases with severe (grade v3) transmural arteritis and/or transmural fibrinoid change and necrosis of smooth muscle cells. Banff 93-95 considers all cases of this type as Grade III rejection. Banff 97 regards severe transmural arteritis as Type IIB rejection, and cases with transmural fibrinoid change or necrosis as Type III rejection. In the Banff 93-95 schema, recent focal infarction and interstitial hemorrhage without other obvious cause are also regarded as evidence for Grade 3 rejection. In Banff 97, these lesions alone are not sufficient to for a diagnosis of Type III rejection.

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