In this photomicrograph there is low grade mononuclear lobular
inflammation, typical of EBV-related hepatitis, like that seen in the general
population with hepatitis related to infectious mononucleosis. Note the slight
increase in sinusoidal lymphocytes and "indian-filing" along the sinusoids.
This histopathological presentation is extremely difficult to differentiate from
non-specific viral hepatitis or low grade viral hepatitis type B or C in an
allograft recipient. The diagnosis of EBV hepatitis can be confirmed or
excluded with the use of in situ hybridization for EBV EBER RNA.