Causes of Graft Dysfunction: Non-Rejection

Infectious Pancreatitis

Graft pancreatitis secondary to infections may occur at any time post-transplantation. The etiology may be bacterial, fungal or viral (cytomegalovirus infection).
Necrotizing bacterial and fungal pancreatitis may result in the formation of intrapancreatic abscesses or formation of cystic cavities.

In bladder drained pancreas transplants, graft pancreatitis can be secondary to reflux of urinary bladder contents in the pancreatic duct.

 

REFERENCES

  1. Drachenberg CB, Papadimitriou JC, Farney A, Wiland A, Blahut S, Fink JC, Philosophe Bk, Schweitzer E, Lal T, Anderson L, Bartlett ST: Pancreas transplantation: the histologic morphology of graft loss and clinical correlations Transplantation 2001;71:1784-91.
  2. Fernandez-Cruz L, Sabater L, Gilabert R, Ricart MJ, Saenz A, Astudillo E: Native and graft pancreatitis following combined pancreas-renal transplantation. Br J Surg 1993;80:1429-32.
  3. Linder R, Tyden G, Tibell A, Groth CG: Late graft pancreatitis. Transplantation 1990;50:257-61.
  4. Backman L, Brattstrom C, Reinholt FP, Andersson J, Tyden G: Development of intrapancreatic abscess- a consequence of CMV pancreatitis?. Transpl Int 1991;4:116-21.
  5. Nobrega J, Halvorsen RA, Letourneau JG, Snover D, Sutherland D: Cystic central necrosis of transplanted pancreas. Gastrointest Radiol 1990;15:202-4.
  6. Boudreaux JP, Nealon WH, Carson RC, Fish JC: Pancreatitis necessitating urinary undiversion in a bladder drained pancreas transplant. Transplant Proc 1990;22:641-2.


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Last Modified: Thu Jun 18 10:14:08 EDT 2009