Late Bile Duct and Parenchymal Changes in Chronic Liver Allograft
In the later stages of chronic rejection, there may be only
mild or even no portal inflammation. Bile ducts loss affects > 50 % of the portal
tracts, and any remaining ducts usually continue to show
atrophy and pyknosis. Within the lobules, cholestasis, foam cell clusters and moderate to severe (bridging)
perivenular fibrosis appear. However, a classic cirrhosis, with portal-to-portal bridging fibrosis; fibrous septae
containing proliferating cholangioles; and regenerative nodules is uncommon in our experience.