Table 1. Sampling of Studies of the Incidence of HCV-induced Hepatitis and Cirrhosis after Liver Transplantation
|
Study |
# Pts |
Hepatitis
% |
CAH % |
Cirrhosis % |
Comments |
|
Shah; Gastroenterology. 1992; 103: 23-9 |
35 |
NA |
13.8 |
0 |
Early study, limited diagnostic tools |
|
Marzano; J Hepatol 1994;21:961-5. |
17 |
NA |
> 90 |
12 |
Hepatitis frequently observed, but low grade chronic disease |
|
Randhawa; Pathol Annu 1995;30:203-26 |
|
44 |
>40 |
10 |
Hepatitis frequently observed, but survival is acceptable; long term impact needs further assessment. |
|
Gane; N Engl J Med 1996; 334:815-20 |
149 |
NA |
81 |
8 |
HCV can cause severe graft injury, long term impact to be assessed |
|
Rosen; Transplantation 1996; 62: 1773-6 |
304 |
NA |
70 |
3 |
Need longer term F/U to assess full impact of recurrent disease activity |
|
Belli; Liver Transpl Surg 1996; 2: 200-5 |
50 |
56/33 |
56/33* |
20/8* |
Genotype 1b more aggressive |
|
Caccamo; Transpl Int 1996; 9 Suppl 1:S204-9 |
35 |
57 |
23 |
10 |
HCV has negative impact over time |
|
Johnson; Arch Surg. 1996;131: 284-91 |
74 |
46 |
16 |
16 |
Despite HCV recurrence, long term survival acceptable; Tacrolimus associated with higher incidence of cirrhosis in HCV recipients |
|
Arnold; Z. Gastroenterol. 1997; 35:255-61 |
18 |
56 |
50 |
11 |
HCV viremia common, but low grade chronic disease; no association of genotypes with clinical course |
|
Gordon; Transplantation 1997; 63: 1419-23 |
42 |
90.4 |
38 |
35/8* |
HCV-induced hepatitis very frequent; genotype 1b shows more aggressive disease and evolution toward cirrhosis |
|
Boker; Hepatology 1997; 25:203-10 |
71 |
88 |
24 |
1.5 |
Generally mild disease, but 10% develop significant fibrosis over decade |
|
Davison; J Hepatol 1998; 28:764-70 |
80 |
NA |
24 |
NA |
Pediatric patients |
|
Berenguer; J Hepatol 1998; 28: 756-63 |
63 |
NA |
75 |
|
Rejection a risk factor for recurrent hepatitis |
