Table 1

Table 1. Sampling of Studies of the Incidence of HCV-induced Hepatitis and Cirrhosis after Liver Transplantation

Study

# Pts

Hepatitis

%

CAH %

Cirrhosis %

Comments

Shah; Gastroenterology. 1992; 103: 23-9

35

NA

13.8

0

Early study, limited diagnostic tools

Marzano; J Hepatol 1994;21:961-5.

17

NA

> 90

12

Hepatitis frequently observed, but low grade chronic disease

Randhawa; Pathol Annu 1995;30:203-26

 

44

>40

10

Hepatitis frequently observed, but survival is acceptable; long term impact needs further assessment.

 Gane; N Engl J Med 1996; 334:815-20

149

NA

81

8

HCV can cause severe graft injury, long term impact to be assessed

 Rosen; Transplantation 1996; 62: 1773-6

304

NA

70

3

Need longer term F/U to assess full impact of recurrent disease activity

 Belli; Liver Transpl Surg 1996; 2: 200-5

50

56/33

56/33*

20/8*

Genotype 1b more aggressive

 Caccamo; Transpl Int 1996; 9 Suppl 1:S204-9

35

57

23

10

HCV has negative impact over time

 Johnson; Arch Surg. 1996;131: 284-91

74

46

16

16

Despite HCV recurrence, long term survival acceptable; Tacrolimus associated with higher incidence of cirrhosis in HCV recipients

 Arnold; Z. Gastroenterol. 1997; 35:255-61

18

56

50

11

HCV viremia common, but low grade chronic disease; no association of genotypes with clinical course

 Gordon; Transplantation 1997; 63: 1419-23

42

90.4

38

35/8*

HCV-induced hepatitis very frequent; genotype 1b shows more aggressive disease and evolution toward cirrhosis

 Boker; Hepatology 1997; 25:203-10

71

88

24

1.5

Generally mild disease, but 10% develop significant fibrosis over decade

 Davison; J Hepatol 1998; 28:764-70

80

NA

24

NA

Pediatric patients

 Berenguer; J Hepatol 1998; 28: 756-63

63

NA

75

 

Rejection a risk factor for recurrent hepatitis

*type 1b/non 1b genotype of HCV

Last Modified: Thu Jun 18 10:14:08 EDT 2009