Pretransplant Acute Endothelial Injury

Pretransplant Acute Endothelial Injury

Pretransplant injury to the kidney endothelium can occur as an agonal event in the donor. An extreme example of this is disseminated intravascular coagulation illustrated in the section on 'Pre-existing disease'. Less severe damage can occur during the harvesting and transportation of the organ prior to actual implantation, particularly if pulsatile perfusion pumps are used, or the organ is flushed with a solution of inappropriate ionic composition. Mild forms of endothelial injury result in endothelial swelling, and scattered microthrombi within the glomerular capillaries and small arterioles.


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Last Modified: Thu Jun 18 10:14:08 EDT 2009