One of the earliest morphological changes seen with
humoral rejection is platelet-fibrin thrombi in the
vasculature. This section was taken 30 minutes after
transplantation of a normal liver into a presensitized
rat recipient. The titer of preformed antibodies was
low enough not to cause precipitous graft failure, but
high enough to affect the pace of the rejection reaction.
Note the margination of platelet in the central veins.
Similar changes are seen in the
portal tracts and