Humoral Rejection

Humoral Rejection
A higher magnification of the centrilobular region of the backtable biopsy shown in previous figure ascertains the integrity of the hepatocytes. Note also the presence of lipofuschin pigment, which is most obvious in the hepatocytes immediately subjacent to the terminal hepatic venule. Not infrequently, a pathologist may be requested by an inexperienced surgeon to examine a donor liver by frozen section because it has an "odd color", which is usually grey-brown. In this circumstance it is important for the pathologist to distinguish bile(cholestasis), from lipofuschin or other pigment, which could influence the decision to use the donor organ for transplantation. In such cases, it is wise to know the donor's age and the serum bilirubin at the time of harvesting. Morphologically, bile is less granular than lipofuschin. In addition, it is wise to look for bile plugs in the canaliculi located between hepatocytes, before making the diagnosis of cholestasis.


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Last Modified: Thu Jun 18 10:14:08 EDT 2009